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Peptide record

TPDB05395

Antibacterial Anticancer Antifungal Antiparasitic standard

27 amino acids

3D PDB MODEL

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TPDB ID TPDB05395

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

ALSILKGLEKLAKMGIALTNCKATKKC

FASTA

>TPDB05395|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=27
ALSILKGLEKLAKMGIALTNCKATKKC

Formula C125H228N34O34S3

Absent Amino Acids RDQHFPWYV

Common Amino Acids K

Mass 2847.57

PI 10.27

Basic Residues 6

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +5

Boman Index 4.00

Hydrophobicity 0.322

Aliphatic Index 115.93

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 4.39

Polar Residues 6

number

Amino Acid Distribution

A: 4 R: 0 N: 1 D: 0 C: 2 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 5 K: 6 M: 1 F: 0 P: 0 S: 1 T: 2 W: 0 Y: 0 V: 0

Length

Formula

C125H228N34O34S3

Mass

2847.57

10.27

Net Charge

Boman Index

4.00

Hydrophobicity

0.322

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 28 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activit

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activity was tested together with pal

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >150 µM

Target

Target Organism C.albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activity was tested together with palustrin-1c. Provided by Erik

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 28 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activit

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activity was tested together with pal

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >150 µM

Target

Target Organism C.albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activity was tested together with palustrin-1c. Provided by Erik

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 28 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activit

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >150 µM

Target

Target Organism S.aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activity was tested together with pal

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >150 µM

Target

Target Organism C.albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC 28 uM) but not S.aureus (MIC>150 uM) and C.albicans (MIC>150 uM). Warning: Antibacterial activity was tested together with palustrin-1c. Provided by Erik