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Peptide record

TPDB05391

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

24 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05391

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP pep-lab Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPVLAGIAAKVVPALFCKITKKC

FASTA

>TPDB05391|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=24
FLPVLAGIAAKVVPALFCKITKKC

Formula C121H204N28O26S2

Absent Amino Acids RNDEQHMSWY

Common Amino Acids AK

Mass 2531.24

PI 10.17

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 14

Net Charge +4

Boman Index -0.50

Hydrophobicity 1.287

Aliphatic Index 134.17

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 4.94

Polar Residues 3

number

Amino Acid Distribution

A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 4 M: 0 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 3

Length

Formula

C121H204N28O26S2

Mass

2531.24

10.17

Net Charge

Boman Index

-0.50

Hydrophobicity

1.287

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism B. Subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain from the mprF regulating

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 34 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain from the mprF regulating system ( Li et al., 2007 ).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism B. Subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain from the mprF regulating

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 34 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain from the mprF regulating system ( Li et al., 2007 ).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism B. Subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain from the mprF regulating

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 34 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain from the mprF regulating system ( Li et al., 2007 ).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism B. Subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain from the mprF regulating

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 34 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 34 ug/ml). More active against a mutant strain from the mprF regulating system ( Li et al., 2007 ).

Evidence 13 Activity

Activity

Detail Source Activity Hemolysis

Hemolysis Raw

[Ref.1449472] high hemolytic activity

Source & Reference

Database Source Hemolytik APD_complete APD_hemolytic PD_Hemolysis

Source DRAMP4

Reference

Biochem Biophys Res Commun. 1992 Nov 30 189(1):184-190.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 89% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 80 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

89% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. | Eur J Clin Microbiol Infect Dis | 2000

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.1449472] high hemolytic activity

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochem Biophys Res Commun. 1992 Nov 30 189(1):184-190.

Evidence 16 Hemolysis

Activity

Hemolysis Raw

[Ref.1449472] high hemolytic activity

Detail Source Activity Hemolysis

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Reference

Biochem Biophys Res Commun. 1992 Nov 30 189(1):184-190.

Source DRAMP4

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.