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Peptide record

TPDB05381

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB05381
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLSKVLGVGKKVLCGVSGLC
Physicochemical Analysis
C90H164N24O24S2
ARNDEQHIMFPTWY
GL
2030.56
9.80
3
0
9
+3
0.28
1.214
148.10
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
6.16
4
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
5
G
0
H
0
I
5
L
3
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 5 H: 0 I: 0 L: 5 K: 3 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 4
Chemical Descriptors
21
C90H164N24O24S2
2030.56
9.80
+3
0.28
1.214
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoni
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aerug
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typh
Evidence 4 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

(MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active agai
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
22 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

C 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 7 Activity

Activity

MIC
Antibacterial
150 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
15 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoni
Evidence 9 Activity

Activity

MIC
Antifungal
2.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aerug
Evidence 10 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typh
Evidence 11 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active agai
Evidence 12 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 13 Activity

Activity

MIC
Antifungal
22 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 14 Activity

Activity

MIC
Antifungal
150 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 15 Activity

Activity

MIC
Antiparasitic
15 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoni
Evidence 16 Activity

Activity

MIC
Antiparasitic
2.5 µg/mL

Target

M. luteus

Source & Reference

DRAMP

Other

Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aerug
Evidence 17 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Active against Gram+ S. aureus (MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typh
Evidence 18 Activity

Activity

MIC
Antiparasitic
10 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

(MIC 15 uM), M. luteus (MIC 2.5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active agai
Evidence 19 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

5 ug/ml), Gram-negative E. coli (MIC 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 20 Activity

Activity

MIC
Antiparasitic
22 µg/mL

Target

S. typhimurium

Source & Reference

DRAMP

Other

C 5 uM), S. dysenteriae, K. pneumoniae (MIC 10 ug/ml), P. aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 21 Activity

Activity

MIC
Antiparasitic
150 µg/mL

Target

C.albicans

Source & Reference

DRAMP

Other

aeruginosa (MIC 100 ug/ml), and S. typhimurium (MIC 22 ug/ml), and weakly active against C.albicans (MIC 150 ug/ml).
Evidence 22 Activity

Activity

1% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata. | FEBS Lett | 2001
Evidence 23 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:11682065] It has 0.9% hemolytic activity at 100µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS Lett. 2001 Oct 19 507(1):95-100.