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Peptide record

TPDB05367

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05367

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GIWDTIKSMGKVFAGKILQNL

FASTA

>TPDB05367|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Toxicity|length=21
GIWDTIKSMGKVFAGKILQNL

Formula C107H175N27O28S1

Absent Amino Acids RCEHPY

Common Amino Acids GIK

Mass 2319.79

PI 10.32

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 10

Net Charge +2

Boman Index 0.14

Hydrophobicity 0.286

Aliphatic Index 111.43

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 237.09

Polar Residues 4

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 3 L: 2 K: 3 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1

Length

Formula

C107H175N27O28S1

Mass

2319.79

10.32

Net Charge

Boman Index

0.14

Hydrophobicity

0.286

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13-25 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immun

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus or MRSA

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 1.65 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13-25 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immun

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus or MRSA

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 1.65 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13-25 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immun

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus or MRSA

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 1.65 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13-25 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immun

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism Staphylococcus aureus or MRSA

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Active against E. coli (MIC 13-25 uM), S. aureus or MRSA (MIC 25 uM), and C. albicans (MIC 25 uM). Virus: inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 1.65 uM).

Evidence 13 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 90 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 90 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial properties of brevinin-2-related peptide and its analogs: Efficacy against multidrug-resistant Acinetobacter baumannii | Chem Biol Drug Des | 2009

Evidence 14 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 7.42 µM

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 7.42 | µM | target cell: CEM-SS cells

Target

Target Cell CEM-SS cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database | Antimicrob Agents Chemother | 2010

Evidence 15 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 70 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.15556063]HC50=70 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct 139(1-3):31-38.