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Peptide record

TPDB05363

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB05363
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept dbAMP 3.0 AI4AVP DRAMP DRAVP 2.0 ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFPCGESCVFIPCISAAIGCSCKNKVCYRN
Physicochemical Analysis
C135H213N37O39S6
DQHLMTW
C
3170.76
8.02
3
1
10
+2
1.20
0.507
65.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
58.82
12
Residue Composition
number
2
A
1
R
2
N
0
D
6
C
1
E
0
Q
3
G
0
H
3
I
0
L
2
K
0
M
2
F
2
P
3
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 0 K: 2 M: 0 F: 2 P: 2 S: 3 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
30
C135H213N37O39S6
3170.76
8.02
+2
1.20
0.507
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 130 nM).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

DRAMP Antifungipept

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 130 nM).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 130 nM).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 130 nM).
Evidence 5 Activity

Activity

IC50
Toxicity
0.56 µM
Cytotoxic
IC50 | 0.56 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Cyclotides as natural anti-HIV agents | Biopolymers | 2008
Evidence 6 Activity

Activity

IC50
Toxicity
560 nM
Cytotoxic
Cytotoxicity: [Ref.18008336]CEM-SS cells:IC50=560 nM.

Source & Reference

NA
DRAMP
J Org Chem. 2000 Jan 14 65(1):124-128.##Biopolymers. 2008 90(1):51-60.