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Peptide record

TPDB05359

Protachykinin-1 Substance P Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB05359
Protachykinin-1 Substance P
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Neuroactive peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP B3Pred BBPpredict CellPPD-MOD CPPsite3.0 ToxinPred 3.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RPKPQQFFGLM
Physicochemical Analysis
C63H97N17O14S1
ANDCEHISTWYV
QFP
1348.63
11.49
2
0
4
+2
0.82
-0.700
35.45
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
2
Q
1
G
0
H
0
I
1
L
1
K
1
M
2
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 1 K: 1 M: 1 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C63H97N17O14S1
1348.63
11.49
+2
0.82
-0.700
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.7 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
It showed a good activity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity agains
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

vity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity aga
Evidence 3 Activity

Activity

MIC
Antibacterial
171 µg/mL

Target

S. mutans NCTC 10449

Source & Reference

dbAMP DRAMP

Other

k activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity against S. mutans NCTC 10449 (MIC 171 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
5.7 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
It showed a good activity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity agains
Evidence 5 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

vity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity aga
Evidence 6 Activity

Activity

MIC
Antifungal
171 µg/mL

Target

S. mutans NCTC 10449

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

k activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity against S. mutans NCTC 10449 (MIC 171 ug/ml).
Evidence 7 Activity

Activity

MIC
Antiparasitic
5.7 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
It showed a good activity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity agains
Evidence 8 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

vity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity aga
Evidence 9 Activity

Activity

MIC
Antiparasitic
171 µg/mL

Target

S. mutans NCTC 10449

Source & Reference

DRAMP

Other

k activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity against S. mutans NCTC 10449 (MIC 171 ug/ml).
Evidence 10 Activity

Activity

MIC
Antiviral
5.7 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
It showed a good activity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity agains
Evidence 11 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

vity against E. coli ATCC 25922 (MIC 5.7 ug/ml), P. aeruginosa ATCC 27853 (15 ug/ml), and C. albicans (MIC 8 ug/ml), weak activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity aga
Evidence 12 Activity

Activity

MIC
Antiviral
171 µg/mL

Target

S. mutans NCTC 10449

Source & Reference

DRAMP

Other

k activity against L acidophilus NCTC 1723 (MIC 74 ug/ml), and very weak activity against S. mutans NCTC 10449 (MIC 171 ug/ml).
Evidence 13 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Mus musculus
Opioid
Evidence 14 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Rattus norvegicus
Tachykinin
Evidence 15 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Bos taurus
Tachykinin
Evidence 16 Activity

Activity

Neuropeptide

Target

Substance-P receptor Substance-K receptor Neuromedin-K receptor
Homo sapiens Homo sapiens Homo sapiens

Source & Reference

NA
NeuroPepV2

Other

Homo sapiens
Tachykinin
407 398 465
NP10738 NP10746 NP10672 NP10682 NP10738 NP10746 NP10672 NP10682 NP10738 NP10746 NP10672 NP10682
Evidence 17 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Mesocricetus auratus
Tachykinin
Evidence 18 Activity

Activity

Neuropeptide

Target

Substance-P receptor
Mus musculus

Source & Reference

NA
NeuroPepV2

Other

Mus musculus
Tachykinin
407
NP10748
Evidence 19 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Oryctolagus cuniculus
Tachykinin
Evidence 20 Activity

Activity

Neuropeptide

Target

Substance-P receptor
Rattus norvegicus

Source & Reference

NA
NeuroPepV2

Other

Rattus norvegicus
Tachykinin
407
NP10741 NP10742 NP10750
Evidence 21 Activity

Activity

Neuropeptide

Target

Substance-P receptor
Cavia porcellus

Source & Reference

NA
NeuroPepV2

Other

Cavia porcellus
Tachykinin
407
NP10751
Evidence 22 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Equus caballus
Tachykinin
Evidence 23 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human pulp fibroblasts

Target

Human pulp fibroblasts

Source & Reference

NA
DBAASP
Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. | J Neuroimmunol | 2008
Additional Detail Fields 3 fields
Opioid Tachykinin
407 398 465
NP10738 NP10746 NP10672 NP10682 NP10748 NP10741 NP10742 NP10750 NP10751