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Peptide record

TPDB05348

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB05348
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIMDSVKGLAKNLAGKLLDSLKCKITGC
Physicochemical Analysis
C124H222N34O37S3
REQHFPWY
LK
2877.51
9.65
5
2
11
+3
3.87
0.314
115.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.34
6
Residue Composition
number
2
A
0
R
1
N
2
D
2
C
0
E
0
Q
4
G
0
H
2
I
5
L
5
K
1
M
0
F
0
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 2 C: 2 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 5 K: 5 M: 1 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
28
C124H222N34O37S3
2877.51
9.65
+3
3.87
0.314
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
17 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 17 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 2 Activity

Activity

MIC
Antifungal
17 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 17 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 3 Activity

Activity

MIC
Antiparasitic
17 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 17 uM). Also active against B. dendrobatidis (Table 1, Rollins-Smith, BBA 2009 1788:1593-1599).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation of peptides of the brevinin-1 family with potent candidacidal activity from the skin secretions of the frog Rana boylii. | J Pept Res | 2003
Evidence 5 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.