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Peptide record

TPDB05324

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

12 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05324

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

RVCYAIPLPICY

FASTA

>TPDB05324|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=12
RVCYAIPLPICY

Formula C66H103N15O15S2

Absent Amino Acids NDEQGHKMFSTW

Common Amino Acids CIPY

Mass 1410.76

PI 8.27

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +1

Boman Index -1.93

Hydrophobicity 1.125

Aliphatic Index 130.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 3105

Absorbance 280nm 220.09

Polar Residues 4

number

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 2 V: 1

Length

Formula

C66H103N15O15S2

Mass

1410.76

8.27

Net Charge

Boman Index

-1.93

Hydrophobicity

1.125

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against B. subtilis (MIC 30 ug/ml), S. aureus ATCC 8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 8530

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against B. subtilis (MIC 30 ug/ml), S. aureus ATCC 8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (M

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 40 µg/mL

Target

Target Organism P. putida NCIM 2102

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ilis (MIC 30 ug/ml), S. aureus ATCC 8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (MIC 30 ug/ml), and yeast S. cerevisiae ATCC 8530 (MIC 80 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 30 µg/mL

Target

Target Organism M. luteus MT 166

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (MIC 30 ug/ml), and yeast S. cerevisiae ATCC 8530 (MIC 80 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 80 µg/mL

Target

Target Organism S. cerevisiae ATCC 8530

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (MIC 30 ug/ml), and yeast S. cerevisiae ATCC 8530 (MIC 80 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against B. subtilis (MIC 30 ug/ml), S. aureus ATCC 8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 8530

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against B. subtilis (MIC 30 ug/ml), S. aureus ATCC 8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (M

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 40 µg/mL

Target

Target Organism P. putida NCIM 2102

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 30 µg/mL

Target

Target Organism M. luteus MT 166

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (MIC 30 ug/ml), and yeast S. cerevisiae ATCC 8530 (MIC 80 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 80 µg/mL

Target

Target Organism S. cerevisiae ATCC 8530

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (MIC 30 ug/ml), and yeast S. cerevisiae ATCC 8530 (MIC 80 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against B. subtilis (MIC 30 ug/ml), S. aureus ATCC 8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 8530

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against B. subtilis (MIC 30 ug/ml), S. aureus ATCC 8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (M

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 40 µg/mL

Target

Target Organism P. putida NCIM 2102

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 30 µg/mL

Target

Target Organism M. luteus MT 166

Source & Reference

Database Source DRAMP

Other

Evidence Text

8530 (MIC 30 ug/ml), E. coli W 160.37 (MIC 40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (MIC 30 ug/ml), and yeast S. cerevisiae ATCC 8530 (MIC 80 ug/ml).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 80 µg/mL

Target

Target Organism S. cerevisiae ATCC 8530

Source & Reference

Database Source DRAMP

Other

Evidence Text

40 ug/ml), P. putida NCIM 2102 (MIC 40 ug/ml), M. luteus MT 166 (MIC 30 ug/ml), and yeast S. cerevisiae ATCC 8530 (MIC 80 ug/ml).

Evidence 16 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement <200 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | <200 | µg/mL | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. | J Biol Chem | 2001

Evidence 17 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.11031261] It exhibits no hemolytic activity up to a concentration of 200 µg/ml against rat erythrocytes.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Biol Chem. 2001 Jan 26 276(4):2701-2707.