Back to search

Peptide record

TPDB05318

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05318
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GIPCAESCVYIPCTVTALLGCSCSNRVCYN
Physicochemical Analysis
C131H211N35O42S6
DQHKMFW
C
3140.69
5.90
1
1
11
-0
0.07
0.747
87.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
106.82
15
Residue Composition
number
2
A
1
R
2
N
0
D
6
C
1
E
0
Q
2
G
0
H
2
I
2
L
0
K
0
M
0
F
2
P
3
S
2
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 0 M: 0 F: 0 P: 2 S: 3 T: 2 W: 0 Y: 2 V: 3
Chemical Descriptors
30
C131H211N35O42S6
3140.69
5.90
-0
0.07
0.747
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

It is toxic to Golden apple snails, serious pests of rice in South East Asia (Plan et al. 2008 J Agric Food Chem 56: 5237).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

It is toxic to Golden apple snails, serious pests of rice in South East Asia (Plan et al. 2008 J Agric Food Chem 56: 5237).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

NA

Other

It is toxic to Golden apple snails, serious pests of rice in South East Asia (Plan et al. 2008 J Agric Food Chem 56: 5237).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
61.6±1.3 µM
Hemolytic Cytotoxic
50% Hemolysis | 61.6±1.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis. | Biopolymers | 2010
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.20575512] Cytotoxicity on the human lymphoma cell line U-937 GTB(IC50 around 1 µM).

Source & Reference

NA
DRAMP
Biochem J. 2006 Nov 15 400(1):1-12.##J Mol Biol. 1999 Dec 17 294(5):1327-1336.##J Biol Chem. 2003 Mar 7 278(10):8606-8616.
Evidence 6 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.