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Peptide record

TPDB05312

Antibacterial Antifungal Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB05312
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis pep-lab ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GGSVPCGESCVFIPCITSLAGCSCKNKVCYYD
Physicochemical Analysis
C140H219N35O45S6
RQHMW
C
3304.85
5.97
2
2
10
-0
1.66
0.481
66.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
101.52
14
Residue Composition
number
1
A
0
R
1
N
1
D
6
C
1
E
0
Q
4
G
0
H
2
I
1
L
2
K
0
M
1
F
2
P
4
S
1
T
0
W
2
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 2 L: 1 K: 2 M: 0 F: 1 P: 2 S: 4 T: 1 W: 0 Y: 2 V: 3
Chemical Descriptors
32
C140H219N35O45S6
3304.85
5.97
-0
1.66
0.481
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

This circular peptide showed no antibacterial activity. However, it is insecticidal presumbly by lysis of insect cells.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

This circular peptide showed no antibacterial activity. However, it is insecticidal presumbly by lysis of insect cells.
Evidence 3 Activity

Activity

% Hemolysis
Hemolysis
28 41 %
[Ref.22074926] It has 28% and 41% hemolysis at 20 µM and 40 µM against human red blood cells.

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Biol Chem. 2012 Jan 2 287(1):134-147.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 4 Activity

Activity

41% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
41% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane. | J Biol Chem | 2012
Evidence 5 Activity

Activity

28% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
28% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane. | J Biol Chem | 2012
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
41 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.22074926] It has 28% and 41% hemolysis at 20 µM and 40 µM against human red blood cells. | Cytotoxicity: [Ref.22074926] It exhibited cytotoxic effects on SF-9 cells with CC50 values to be 1.7 µm at 24 h, 10.3 µm at 48 h and 73.1 µm at 72 h.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2012 Jan 2 287(1):134-147.
Evidence 7 Hemolysis

Activity

28 41 %
% Hemolysis
[Ref.22074926] It has 28% and 41% hemolysis at 20 µM and 40 µM against human red blood cells.
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Biol Chem. 2012 Jan 2 287(1):134-147.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.