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Peptide record

TPDB05307

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

17 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05307

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

SAPRGCWTKSYPPKPCK

FASTA

>TPDB05307|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=17
SAPRGCWTKSYPPKPCK

Formula C85H132N24O22S2

Absent Amino Acids NDEQHILMFV

Common Amino Acids P

Mass 1906.25

PI 10.08

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +4

Boman Index 2.55

Hydrophobicity -1.218

Aliphatic Index 5.88

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7115

Absorbance 280nm 373.25

Polar Residues 6

number

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 4 S: 2 T: 1 W: 1 Y: 1 V: 0

Length

Formula

C85H132N24O22S2

Mass

1906.25

10.08

Net Charge

Boman Index

2.55

Hydrophobicity

-1.218

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9 µM

Target

Target Organism Y. pseudotuberculosis YP III

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against Gram- Y. pseudotuberculosis YP III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 80 µM

Target

Target Organism s. syringae pv tabaci

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against Gram- Y. pseudotuberculosis YP III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Gram- Y. pseudotuberculosis YP III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7 µM

Target

Target Organism S. lentus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM),

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

yringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.4 µM

Target

Target Organism C. tropicalis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.4 µM

Target

Target Organism C. guiller-mondii

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µM

Target

Target Organism P. nicotianae spores

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

, M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9 µM

Target

Target Organism Y. pseudotuberculosis YP III

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against Gram- Y. pseudotuberculosis YP III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 80 µM

Target

Target Organism s. syringae pv tabaci

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against Gram- Y. pseudotuberculosis YP III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7 µM

Target

Target Organism S. lentus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM),

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.4 µM

Target

Target Organism C. tropicalis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.4 µM

Target

Target Organism C. guiller-mondii

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 32 µM

Target

Target Organism P. nicotianae spores

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

, M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9 µM

Target

Target Organism Y. pseudotuberculosis YP III

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against Gram- Y. pseudotuberculosis YP III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 80 µM

Target

Target Organism s. syringae pv tabaci

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against Gram- Y. pseudotuberculosis YP III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3 µM

Target

Target Organism B. megaterium Bm11

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7 µM

Target

Target Organism S. lentus

Source & Reference

Database Source DRAMP

Other

Evidence Text

III (MIC 9 uM), Ps. syringae pv tabaci (MIC 80 uM), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM),

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 5 µM

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 7.4 µM

Target

Target Organism C. tropicalis

Source & Reference

Database Source DRAMP

Other

Evidence Text

), Gram+ B. megaterium Bm11 (MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.4 µM

Target

Target Organism C. guiller-mondii

Source & Reference

Database Source DRAMP

Other

Evidence Text

(MIC 3 uM), S. lentus (MIC 7 uM), M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 32 µM

Target

Target Organism P. nicotianae spores

Source & Reference

Database Source DRAMP

Other

Evidence Text

, M. luteus (MIC 5 uM), fungi C. tropicalis (MIC 7.4 uM), C. guiller-mondii (MIC 3.4 uM), P. nicotianae spores (MIC 32 uM).

Evidence 25 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 55 %

Hemolysis Raw

[Ref.14636071] It has 55% hemolytic activity at 100 µM against human erythrocytes

Target

RBC Target human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete APD_hemolytic PD_Hemolysis

Source DRAMP4

Reference

Biochemistry. 2003 Dec 2 42(47):14023-14035.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 26 Activity

Activity

Activity Endpoint 55% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

55% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Ranacyclins, a new family of short cyclic antimicrobial peptides: biological function, mode of action, and parameters involved in target specificity. | Biochemistry | 2003

Evidence 27 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.14636071] It has 55% hemolytic activity at 100 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochemistry. 2003 Dec 2 42(47):14023-14035.

Evidence 28 Hemolysis

Activity

Activity Measurement 55 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.14636071] It has 55% hemolytic activity at 100 µM against human erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Reference

Biochemistry. 2003 Dec 2 42(47):14023-14035.

Source DRAMP4

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.