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Peptide record

TPDB05306

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05306
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFPIIAGMAAKVICAITKKC
Physicochemical Analysis
C99H165N23O22S3
RNDEQHLSWY
AI
2125.72
9.80
3
0
12
+3
-1.25
1.375
112.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
5.88
3
Residue Composition
number
4
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
4
I
0
L
3
K
1
M
2
F
1
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 0 K: 3 M: 1 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C99H165N23O22S3
2125.72
9.80
+3
-1.25
1.375
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
13 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 3 Activity

Activity

MIC
Antibacterial
3 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 4 Activity

Activity

MIC
Antifungal
13 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 5 Activity

Activity

MIC
Antifungal
3 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 6 Activity

Activity

MIC
Antifungal
3 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 7 Activity

Activity

MIC
Antiparasitic
13 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 8 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 9 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 10 Activity

Activity

MIC
Antiviral
13 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 11 Activity

Activity

MIC
Antiviral
3 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 12 Activity

Activity

MIC
Antiviral
3 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

Activity against E. coli (MIC 13 uM), S. aureus (MIC 3 uM), and C. albicans (MIC 3 uM). Updated 3/2012 5/2018 GW.
Evidence 13 Activity

Activity

HC50
Hemolysis
8 µM
[Ref.15556063]HC50=8 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct 139(1-3):31-38.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
50% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis) | Comp Biochem Physiol C Toxicol Pharmacol | 2004
Evidence 15 Activity

Activity

HC50
Toxicity
8 µM
Hemolytic
Hemolytic_activity: [Ref.15556063]HC50=8 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct 139(1-3):31-38.
Evidence 16 Hemolysis

Activity

8 µM
HC50
[Ref.15556063]HC50=8 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct 139(1-3):31-38.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.