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Peptide record

TPDB05302

Macropin 1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05302
Macropin 1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFGMALKLLKKVL
Physicochemical Analysis
C68H120N16O14S1
RNDCEQHIPSTWY
L
1417.86
10.84
3
0
8
+3
-0.71
1.031
150.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
4
L
3
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C68H120N16O14S1
1417.86
10.84
+3
-0.71
1.031
Free
L
Not Available
Free
Antibacterial
Venom, the solitary beeMacropis fulvipes
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.3 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P.
Evidence 2 Activity

Activity

MIC
Antibacterial
3.7 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

L. monocytogenes KCTC 3710

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albi
Evidence 4 Activity

Activity

MIC
Antibacterial
3.0 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Add
Evidence 5 Activity

Activity

MIC
Antibacterial
6.25-35 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

M), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Additional data from Ko et al., 201
Evidence 6 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Additional data from Ko et al., 2017 .
Evidence 7 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 8 Activity

Activity

MIC
Antifungal
1.3 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P.
Evidence 9 Activity

Activity

MIC
Antifungal
3.7 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35
Evidence 10 Activity

Activity

MIC
Antifungal
25 µM

Target

L. monocytogenes KCTC 3710

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albi
Evidence 11 Activity

Activity

MIC
Antifungal
3.0 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Add
Evidence 12 Activity

Activity

MIC
Antifungal
6.25-35 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Additional data from Ko et al., 201
Evidence 13 Activity

Activity

MIC
Antifungal
6.3 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Additional data from Ko et al., 2017 .
Evidence 14 Activity

Activity

MIC
Antiparasitic
1.3 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P.
Evidence 15 Activity

Activity

MIC
Antiparasitic
3.7 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35
Evidence 16 Activity

Activity

MIC
Antiparasitic
25 µM

Target

L. monocytogenes KCTC 3710

Source & Reference

DRAMP

Other

Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albi
Evidence 17 Activity

Activity

MIC
Antiparasitic
3.0 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Add
Evidence 18 Activity

Activity

MIC
Antiparasitic
6.25-35 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

M), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Additional data from Ko et al., 201
Evidence 19 Activity

Activity

MIC
Antiparasitic
6.3 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Additional data from Ko et al., 2017 .
Evidence 20 Activity

Activity

MIC
Antiviral
1.3 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P.
Evidence 21 Activity

Activity

MIC
Antiviral
3.7 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35
Evidence 22 Activity

Activity

MIC
Antiviral
25 µM

Target

L. monocytogenes KCTC 3710

Source & Reference

DRAMP

Other

Active against B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albi
Evidence 23 Activity

Activity

MIC
Antiviral
3.0 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

B. subtilis (MIC 1.3 uM), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Add
Evidence 24 Activity

Activity

MIC
Antiviral
6.25-35 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

M), S. aureus (MIC 3.7 uM), L. monocytogenes KCTC 3710 (MIC 25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Additional data from Ko et al., 201
Evidence 25 Activity

Activity

MIC
Antiviral
6.3 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

25 uM), E. coli (MIC 3.0 uM), P. aeruginosa (MIC 6.25-35 uM), E. coli (MIC 6.25 uM(, and C. albicans (MIC 6.3 uM). Additional data from Ko et al., 2017 .
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
165 µM
Hemolytic Cytotoxic
50% Hemolysis | 165 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 27 Activity

Activity

IC50
Toxicity
28±6 µM
Cytotoxic
IC50 | 28±6 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 28 Activity

Activity

IC50
Toxicity
27±7 µM
Cytotoxic
IC50 | 27±7 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 29 Activity

Activity

18% Cytotoxicity
Toxicity
25 µM
Cytotoxic
18% Cytotoxicity | 25 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Macropis fulvipes Venom component Macropin Exerts its Antibacterial and Anti-Biofilm Properties by Damaging the Plasma Membranes of Drug Resistant Bacteria. | Sci Rep | 2017
Evidence 30 Activity

Activity

5% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
5% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Macropis fulvipes Venom component Macropin Exerts its Antibacterial and Anti-Biofilm Properties by Damaging the Plasma Membranes of Drug Resistant Bacteria. | Sci Rep | 2017
Evidence 31 Activity

Activity

LC50
Toxicity
160 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.24616110] LC50=160 µM against human red blood cells. ##[Ref.29185466]5% hemolysis at 25 µM against red blood cells, 93% hemolysis at 50 µM against red blood cells | Cytotoxicity: [Ref.29185466] In HaCaT cells, Macropin produced cell survival rates of 82% and 41% at peptide concentrations of 25 and 50 µM.## In Raw cells, Macropin produce cell survival rates of 41% and 0% at peptide concentrations of 25 and 50 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2014 Jun 20(6):375-84. doi: 10.1002/psc.2625. Epub 2014 Mar 11.## Sci Rep. 2017 Nov 29 7(1):16580. doi: 10.1038/s41598-017-16784-6.