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Peptide record

TPDB05291

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB05291
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GVLGTVKNLLIGAGKSAAQSVLKTLSCKLSNDC
Physicochemical Analysis
C141H250N40O45S2
REHMFPWY
L
3289.90
9.72
4
1
13
+3
3.00
0.439
118.18
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.80
11
Residue Composition
number
3
A
0
R
2
N
1
D
2
C
0
E
1
Q
4
G
0
H
1
I
6
L
4
K
0
M
0
F
0
P
4
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 1 C: 2 E: 0 Q: 1 G: 4 H: 0 I: 1 L: 6 K: 4 M: 0 F: 0 P: 0 S: 4 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
33
C141H250N40O45S2
3289.90
9.72
+3
3.00
0.439
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 25 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 25 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 25 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
25 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 25 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 25 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 25 uM), and C.albicans ATCC 90028 (MIC > 100 uM).
Evidence 7 Activity

Activity

LC50
Hemolysis
180 µM
[Ref.16621155] LC50=180 µM against human erythrocytes.

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides. 2006 Sep 27(9):2111-2117.##Mol Cell Proteomics. 2007 May 6(5):882-894.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
180 µM
Hemolytic Cytotoxic
50% Hemolysis | 180 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami. | Peptides | 2006
Evidence 9 Activity

Activity

LC50
Toxicity
180 µM
Hemolytic
Hemolytic_activity: [Ref.16621155] LC50=180 µM against human erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2006 Sep 27(9):2111-2117.##Mol Cell Proteomics. 2007 May 6(5):882-894.
Evidence 10 Hemolysis

Activity

180 µM
LC50
[Ref.16621155] LC50=180 µM against human erythrocytes.
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides. 2006 Sep 27(9):2111-2117.##Mol Cell Proteomics. 2007 May 6(5):882-894.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.