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Peptide record

TPDB05290

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB05290
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VFQFLGRIIHHVGNFVHGFSHVF
Physicochemical Analysis
C131H184N36O27
ADCEKMPTWY
F
2695.13
11.05
5
0
12
+1
-0.74
0.752
101.30
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
1
Q
3
G
4
H
2
I
1
L
0
K
0
M
5
F
0
P
1
S
0
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 4 I: 2 L: 1 K: 0 M: 0 F: 5 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 4
Chemical Descriptors
23
C131H184N36O27
2695.13
11.05
+1
-0.74
0.752
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ref). Recent microdilution assays revealed that the MIC value was reduced 32 fold against E. faecalis ATCC 29212 (MIC 8 ug/ml) in the presence of metals (Zn2+ or Cu2+), while the activity against C. albicans ATCC 102
Evidence 2 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP DRAMP

Other

29212 (MIC 8 ug/ml) in the presence of metals (Zn2+ or Cu2+), while the activity against C. albicans ATCC 10231 (MIC 64 ug/ml) was essentially not changed (64-128 uM) in the presnece of Zn2+ or Cu2+ ( Miller et al.,
Evidence 3 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ref). Recent microdilution assays revealed that the MIC value was reduced 32 fold against E. faecalis ATCC 29212 (MIC 8 ug/ml) in the presence of metals (Zn2+ or Cu2+), while the activity against C. albicans ATCC 102
Evidence 4 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

29212 (MIC 8 ug/ml) in the presence of metals (Zn2+ or Cu2+), while the activity against C. albicans ATCC 10231 (MIC 64 ug/ml) was essentially not changed (64-128 uM) in the presnece of Zn2+ or Cu2+ ( Miller et al.,
Evidence 5 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
ref). Recent microdilution assays revealed that the MIC value was reduced 32 fold against E. faecalis ATCC 29212 (MIC 8 ug/ml) in the presence of metals (Zn2+ or Cu2+), while the activity against C. albicans ATCC 102
Evidence 6 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP 3.0 DRAMP

Other

29212 (MIC 8 ug/ml) in the presence of metals (Zn2+ or Cu2+), while the activity against C. albicans ATCC 10231 (MIC 64 ug/ml) was essentially not changed (64-128 uM) in the presnece of Zn2+ or Cu2+ ( Miller et al.,
Evidence 7 Activity

Activity

MIC
Antiviral
8 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
ref). Recent microdilution assays revealed that the MIC value was reduced 32 fold against E. faecalis ATCC 29212 (MIC 8 ug/ml) in the presence of metals (Zn2+ or Cu2+), while the activity against C. albicans ATCC 102
Evidence 8 Activity

Activity

MIC
Antiviral
64 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

29212 (MIC 8 ug/ml) in the presence of metals (Zn2+ or Cu2+), while the activity against C. albicans ATCC 10231 (MIC 64 ug/ml) was essentially not changed (64-128 uM) in the presnece of Zn2+ or Cu2+ ( Miller et al.,
Evidence 9 Activity

Activity

50% Cell death
Toxicity
37.1 µM
Cytotoxic
50% Cell death | 37.1 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010
Evidence 10 Activity

Activity

0% Cell death
Toxicity
256 µg/mL
Cytotoxic
0% Cell death | 256 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes. | Inorg Chem | 2021
Evidence 11 Activity

Activity

0% Cell death
Toxicity
128 µg/mL
Cytotoxic
0% Cell death | 128 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Chemical "Butterfly Effect" Explaining the Coordination Chemistry and Antimicrobial Properties of Clavanin Complexes. | Inorg Chem | 2021