Peptide record

TPDB05279

Neuropeptide Y Pro-neuropeptide Y Antibacterial Anticancer Antifungal Antiparasitic Antiviral Neuropeptide Toxicity standard

36 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05279

Peptide_Name

Neuropeptide Y Pro-neuropeptide Y

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Neuropeptide Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Neuroactive peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AI4AVP

Sequence_Type

standard

Has_Modification No

Description A 36-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY

FASTA

>TPDB05279|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Neuropeptide;Toxicity|length=36
YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY

Formula C189H284N54O58S1

Absent Amino Acids CFWV

Common Amino Acids Y

Mass 4272.72

PI 7.60

Basic Residues 6

Acidic Residues 5

Hydrophobic Residues 14

Net Charge +0

Boman Index 9.20

Hydrophobicity -1.194

Aliphatic Index 54.44

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 7450

Absorbance 280nm 174.36

Polar Residues 11

number

Amino Acid Distribution

A: 4 R: 4 N: 2 D: 3 C: 0 E: 2 Q: 1 G: 1 H: 1 I: 2 L: 2 K: 1 M: 1 F: 0 P: 4 S: 2 T: 1 W: 0 Y: 5 V: 0

Length

Formula

C189H284N54O58S1

Mass

4272.72

7.60

Net Charge

Boman Index

9.20

Hydrophobicity

-1.194

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Alligator mississippiensis

Family NPY

Evidence 2 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2

Receptor Organisms Cavia porcellus Cavia porcellus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Cavia porcellus

Family NPY

Receptor Lengths 383 381

Receptor Ligands NP07601 NP07601

Evidence 3 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Prolactin-releasing peptide receptor Probable G-protein coupled receptor 83 Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 4 Neuropeptide Y receptor type 5 Putative neuropeptide Y receptor type 6 Neuropeptide Y receptor type 4-2

Receptor Organisms Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family NPY

Receptor Lengths 370 423 384 381 375 445 290 375

Receptor Ligands NP07551 NP07607 NP08561 NP08566 NP08567 NP06204 NP06208 NP07551 NP07607 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07551 NP07607 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720

Evidence 4 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 2

Receptor Organisms Macaca mulatta

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Macaca mulatta

Family NPY

Receptor Lengths 381

Receptor Ligands NP07553 NP07610

Evidence 5 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Probable G-protein coupled receptor 83 Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 2 Neuropeptide Y receptor type 4 Neuropeptide Y receptor type 5 Neuropeptide Y receptor type 6

Receptor Organisms Mus musculus Mus musculus Mus musculus Mus musculus Mus musculus Mus musculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family NPY

Receptor Lengths 423 382 381 375 466 371

Receptor Ligands NP07554 NP07611 NP07554 NP07611 NP07657 NP07690 NP07696 NP07554 NP07611 NP07657 NP07690 NP07696 NP07554 NP07611 NP07657 NP07690 NP07696 NP07554 NP07611 NP07657 NP07690 NP07696 NP07554 NP07611 NP07657 NP07690 NP07696

Evidence 6 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 6

Receptor Organisms Oryctolagus cuniculus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Oryctolagus cuniculus

Family NPY

Receptor Lengths 371

Receptor Ligands NP07615 NP07692 NP07698

Evidence 7 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Neuropeptide Y receptor type 1 Neuropeptide Y receptor type 4 Neuropeptide Y receptor type 5

Receptor Organisms Rattus norvegicus Rattus norvegicus Rattus norvegicus

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Rattus norvegicus

Family NPY

Receptor Lengths 382 375 445

Receptor Ligands NP07557 NP07616 NP07693 NP07699 NP07557 NP07616 NP07693 NP07699 NP07557 NP07616 NP07693 NP07699

Evidence 8 Activity

Activity

Detail Source Activity Neuropeptide

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Mus musculus

Family ProSAAS

Evidence 9 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Broad spectrum antibiotic activity of the skin-PYY. | FEBS Lett | 1996

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Murine macrophages

Target

Target Cell Murine macrophages

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Broad spectrum antibiotic activity of the skin-PYY. | FEBS Lett | 1996

Evidence 11 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human pulp fibroblasts

Target

Target Cell Human pulp fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. | J Neuroimmunol | 2008

Family

NPY ProSAAS

Receptor_Lengths

383 381 370 423 384 375 445 290 382 466 371

Receptor_Ligands

NP07601 NP07551 NP07607 NP08561 NP08566 NP08567 NP06204 NP06208 NP07652 NP07689 NP07695 NP07718 NP07719 NP07720 NP07553 NP07610 NP07554 NP07611 NP07657 NP07690 NP07696 NP07615 NP07692 NP07698 NP07557 NP07616 NP07693 NP07699