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Peptide record

TPDB05277

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB05277
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIFGKILGVGKKVLCGLSGMC
Physicochemical Analysis
C93H162N24O23S3
ARNDEQHPTWY
G
2080.64
9.80
3
0
9
+3
-0.84
1.124
120.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
6.01
3
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
6
G
0
H
2
I
3
L
3
K
1
M
1
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 2 L: 3 K: 3 M: 1 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
21
C93H162N24O23S3
2080.64
9.80
+3
-0.84
1.124
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 15 uM), S. aureus (MIC 8 uM), MRSA (MIC 8 uM), and C. albicans (MIC 31 uM). Provided by Biswajit
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 15 uM), S. aureus (MIC 8 uM), MRSA (MIC 8 uM), and C. albicans (MIC 31 uM). Provided by Biswajit Mishra. Updated 7/202
Evidence 3 Activity

Activity

MIC
Antibacterial
31 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 15 uM), S. aureus (MIC 8 uM), MRSA (MIC 8 uM), and C. albicans (MIC 31 uM). Provided by Biswajit Mishra. Updated 7/2021
Evidence 4 Activity

Activity

MIC
Antifungal
15 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 15 uM), S. aureus (MIC 8 uM), MRSA (MIC 8 uM), and C. albicans (MIC 31 uM). Provided by Biswajit
Evidence 5 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 15 uM), S. aureus (MIC 8 uM), MRSA (MIC 8 uM), and C. albicans (MIC 31 uM). Provided by Biswajit Mishra. Updated 7/202
Evidence 6 Activity

Activity

MIC
Antifungal
31 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 15 uM), S. aureus (MIC 8 uM), MRSA (MIC 8 uM), and C. albicans (MIC 31 uM). Provided by Biswajit Mishra. Updated 7/2021
Evidence 7 Activity

Activity

% Hemolysis
Hemolysis
4.2 %
[Ref:22917879] It has 88.4 ± 4.2% hemolytic activity at 128 µg/ml against rabbit red blood cells

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Proteomics. 2012 Oct 22 75(18):5807-5821.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

88% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
88% Hemolysis | 128 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: de novo sequencing and analysis of tandem mass spectrometry data. | J Proteomics | 2012
Evidence 9 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:22917879] It has 88.4 ± 4.2% hemolytic activity at 128 µg/ml against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Proteomics. 2012 Oct 22 75(18):5807-5821.
Evidence 10 Hemolysis

Activity

4.2 %
% Hemolysis
[Ref:22917879] It has 88.4 ± 4.2% hemolytic activity at 128 µg/ml against rabbit red blood cells
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Proteomics. 2012 Oct 22 75(18):5807-5821.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.