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Peptide record

TPDB05269

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB05269
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RWGRWLRKIRRWRPK
Physicochemical Analysis
C100H160N38O16
ANDCEQHMFSTYV
R
2150.62
13.10
8
0
5
+8
0.88
-2.080
52.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
767.22
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
1
L
2
K
0
M
0
F
1
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
15
C100H160N38O16
2150.62
13.10
+8
0.88
-2.080
Evidence Records 3 records
Evidence 1 Activity

Activity

23% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
23% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of structural modification of antimicrobial peptides on their antimicrobial activity, hemolytic activity, and plasma stability. | J Pept Sci | 2021
Evidence 2 Activity

Activity

5% Killing
Toxicity
28 µM
Cytotoxic
5% Killing | 28 | µM | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
The effect of structural modification of antimicrobial peptides on their antimicrobial activity, hemolytic activity, and plasma stability. | J Pept Sci | 2021
Evidence 3 Activity

Activity

10% Killing
Toxicity
28 µM
Cytotoxic
10% Killing | 28 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
The effect of structural modification of antimicrobial peptides on their antimicrobial activity, hemolytic activity, and plasma stability. | J Pept Sci | 2021