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Peptide record

TPDB05264

Antibacterial Antifungal Antiviral Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB05264
Antibacterial Antifungal Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
IPLRGAFINGRWDSQCHRFSNGAIACA
Physicochemical Analysis
C129H198N42O35S2
EKMTYV
A
2961.37
9.19
4
1
11
+2
0.02
-0.033
72.59
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5625
189.95
7
Residue Composition
number
4
A
3
R
2
N
1
D
2
C
0
E
1
Q
3
G
1
H
3
I
1
L
0
K
0
M
2
F
1
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 3 N: 2 D: 1 C: 2 E: 0 Q: 1 G: 3 H: 1 I: 3 L: 1 K: 0 M: 0 F: 2 P: 1 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
27
C129H198N42O35S2
2961.37
9.19
+2
0.02
-0.033
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

It is uncommon that an amphibian peptide is specifically active against human H1 Hemagglutinin-Bearing Influenza A Viruses (IAV H1N1). The IC50 of urumin was 3.8 uM. No activity against other viruses tested.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

It is uncommon that an amphibian peptide is specifically active against human H1 Hemagglutinin-Bearing Influenza A Viruses (IAV H1N1). The IC50 of urumin was 3.8 uM. No activity against other viruses tested.
Evidence 3 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It is uncommon that an amphibian peptide is specifically active against human H1 Hemagglutinin-Bearing Influenza A Viruses (IAV H1N1). The IC50 of urumin was 3.8 uM. No activity against other viruses tested.
Evidence 4 Activity

Activity

<5% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
<5% Hemolysis | 160 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses. | Immunity | 2017