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Peptide record

TPDB05263

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB05263
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
FLPAIAGILSQLF
Physicochemical Analysis
C69H108N14O16
RNDCEHKMTWYV
L
1389.70
6.02
0
0
9
-0
-3.73
1.792
165.38
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
2
I
3
L
0
K
0
M
2
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 3 K: 0 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C69H108N14O16
1389.70
6.02
-0
-3.73
1.792
Evidence Records 5 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
5 20 30 60 88 95 %
[Ref.11738090]5% hemolytic activity at 1 nmol/ml, 20% hemolytic activity at 1.5nmol/ml, 30% hemolytic activity at 2nmol/ml, 60% hemolytic activity at 2.5nmol/ml, 88% hemolytic activity at 3nmol/ml, 95% hemolytic activity at 3.5nmol/ml against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 1990 Mar 26 1033(3):318-323.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

20% Hemolysis
Toxicity
1.5 µM
Hemolytic Cytotoxic
20% Hemolysis | 1.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of bioactive peptides from skin extracts of Rana esculenta. | Biochim Biophys Acta | 1990
Evidence 3 Activity

Activity

70% Hemolysis
Toxicity
3 µM
Hemolytic Cytotoxic
70% Hemolysis | 3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of bioactive peptides from skin extracts of Rana esculenta. | Biochim Biophys Acta | 1990
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11738090]5% hemolytic activity at 1 nmol/ml, 20% hemolytic activity at 1.5nmol/ml, 30% hemolytic activity at 2nmol/ml, 60% hemolytic activity at 2.5nmol/ml, 88% hemolytic activity at 3nmol/ml, 95% hemolytic activity at 3.5nmol/ml against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 1990 Mar 26 1033(3):318-323.
Evidence 5 Hemolysis

Activity

5 20 30 60 88 95 %
% Hemolysis
[Ref.11738090]5% hemolytic activity at 1 nmol/ml, 20% hemolytic activity at 1.5nmol/ml, 30% hemolytic activity at 2nmol/ml, 60% hemolytic activity at 2.5nmol/ml, 88% hemolytic activity at 3nmol/ml, 95% hemolytic activity at 3.5nmol/ml against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochim Biophys Acta. 1990 Mar 26 1033(3):318-323.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.