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Peptide record

TPDB05262

Antibacterial Antifungal Hemolysis Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05262

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GIFGKILGAGKKVLCGLSGLC

FASTA

>TPDB05262|Antibacterial;Antifungal;Hemolysis;Toxicity|length=21
GIFGKILGAGKKVLCGLSGLC

Formula C92H160N24O23S2

Absent Amino Acids RNDEQHMPTWY

Common Amino Acids G

Mass 2034.55

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +3

Boman Index -1.41

Hydrophobicity 1.100

Aliphatic Index 130.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.14

Polar Residues 3

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 2 L: 4 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C92H160N24O23S2

Mass

2034.55

9.80

Net Charge

Boman Index

-1.41

Hydrophobicity

1.100

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 16 uM), S. aureus (MIC 16 uM), and C. albicans (MIC 63 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 16 uM), S. aureus (MIC 16 uM), and C. albicans (MIC 63 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 63 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 16 uM), S. aureus (MIC 16 uM), and C. albicans (MIC 63 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 16 uM), S. aureus (MIC 16 uM), and C. albicans (MIC 63 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 16 uM), S. aureus (MIC 16 uM), and C. albicans (MIC 63 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 63 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 16 uM), S. aureus (MIC 16 uM), and C. albicans (MIC 63 uM).

Evidence 7 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 5.5 %

Hemolysis Raw

[Ref:22917879] It has 80.3 ± 5.5% hemolytic activity at 128 µg/ml against rabbit red blood cells

Target

RBC Target rabbit red blood cells

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

J Proteomics. 2012 Oct 22 75(18):5807-5821.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 8 Activity

Activity

Activity Endpoint 80% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

80% Hemolysis | 128 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: de novo sequencing and analysis of tandem mass spectrometry data. | J Proteomics | 2012

Evidence 9 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:22917879] It has 80.3 ± 5.5% hemolytic activity at 128 µg/ml against rabbit red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Proteomics. 2012 Oct 22 75(18):5807-5821.

Evidence 10 Hemolysis

Activity

Activity Measurement 5.5 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref:22917879] It has 80.3 ± 5.5% hemolytic activity at 128 µg/ml against rabbit red blood cells

Detail Source Activity Hemolysis

Target

RBC Target rabbit red blood cells

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

J Proteomics. 2012 Oct 22 75(18):5807-5821.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.