Back to search

Peptide record

TPDB05258

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05258
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFRDVLKGAAKAFVKTVAGHIAN
Physicochemical Analysis
C108H176N32O28
CEQMPSWY
A
2370.78
10.83
5
1
12
+3
2.79
0.313
93.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
5
A
1
R
1
N
1
D
0
C
0
E
0
Q
3
G
1
H
1
I
1
L
3
K
0
M
2
F
0
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 1 L: 1 K: 3 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
23
C108H176N32O28
2370.78
10.83
+3
2.79
0.313
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3-6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
C-terminally amidated form is more active. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermid
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

y amidated form is more active. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococc
Evidence 3 Activity

Activity

MIC
Antibacterial
6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP

Other

ive. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
6 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

(MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
3-6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
C-terminally amidated form is more active. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermid
Evidence 7 Activity

Activity

MIC
Antifungal
25 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

y amidated form is more active. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococc
Evidence 8 Activity

Activity

MIC
Antifungal
6 µM

Target

Enterobacter cloacae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ive. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
6 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
3-6 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
C-terminally amidated form is more active. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermid
Evidence 12 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

y amidated form is more active. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococc
Evidence 13 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Enterobacter cloacae

Source & Reference

DRAMP

Other

ive. The amidated form is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 14 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

is active against E. coli (MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

(MIC 3-6 uM), P. aeruginosa (MIC 25 uM), E. cloacae (MIC 6 uM), K. pneumoniae (MIC 6 uM), S. epidermidis (MIC 50 uM), Streptococcus Group B (MIC 13 uM).
Evidence 16 Activity

Activity

HC50
Hemolysis
200 µM
[Ref.15207717]HC50>200 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochem Biophys Res Commun. 2004 Jul 16 320(1):170-175.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei. | Biochem Biophys Res Commun | 2004
Evidence 18 Activity

Activity

50% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
50% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Computational design of highly selective antimicrobial peptides. | J Chem Inf Model | 2009
Evidence 19 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic
Hemolytic_activity: [Ref.15207717]HC50>200 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2004 Jul 16 320(1):170-175.
Evidence 20 Hemolysis

Activity

200 µM
HC50
[Ref.15207717]HC50>200 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochem Biophys Res Commun. 2004 Jul 16 320(1):170-175.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.