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Peptide record

TPDB05246

Chrysophsin-1 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB05246
Chrysophsin-1
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFGWLIKGAIHAGKAIHGLIHRRRH
Physicochemical Analysis
C136H211N45O26
NDCEQMPSTYV
GHI
2892.46
12.71
9
0
12
+5
1.31
-0.000
105.60
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
190.15
0
Residue Composition
number
3
A
3
R
0
N
0
D
0
C
0
E
0
Q
4
G
4
H
4
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 4 I: 4 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C136H211N45O26
2892.46
12.71
+5
1.31
-0.000
Free
L
Not Available
Free
Antibacterial
Red sea bream,Chrysophrys majororPagrus major
Evidence Records 29 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

S. iniae F-8502

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 2.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 2.5 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harve
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

V. anguillarum ATCC 19264

Source & Reference

dbAMP DRAMP

Other

inst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 2.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 2.5 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 2.5 uM), V. vul
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

A. salmonicida NCMB 1102

Source & Reference

dbAMP DRAMP

Other

MIC 2.5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 4 Activity

Activity

MIC
Antibacterial
40 µM

Target

P. putida ATCC 12633

Source & Reference

dbAMP DRAMP

Other

C 33148) (MIC 5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activity (MLC): B. subtilis ATCC 6633 (ML
Evidence 5 Activity

Activity

Not Available
Anticancer

Target

Breast Cancer
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2003

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 6 Activity

Activity

MIC
Antifungal
2.5 µM

Target

S. iniae F-8502

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 2.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 2.5 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harve
Evidence 7 Activity

Activity

MIC
Antifungal
2.5 µM

Target

V. anguillarum ATCC 19264

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 2.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 2.5 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 2.5 uM), V. vul
Evidence 8 Activity

Activity

MIC
Antifungal
10 µM

Target

A. salmonicida NCMB 1102

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 2.5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 9 Activity

Activity

MIC
Antifungal
40 µM

Target

P. putida ATCC 12633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 33148) (MIC 5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activity (MLC): B. subtilis ATCC 6633 (ML
Evidence 10 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

S. iniae F-8502

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 2.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 2.5 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harve
Evidence 11 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

V. anguillarum ATCC 19264

Source & Reference

DRAMP

Other

inst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 2.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 2.5 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 2.5 uM), V. vul
Evidence 12 Activity

Activity

MIC
Antiparasitic
10 µM

Target

A. salmonicida NCMB 1102

Source & Reference

DRAMP

Other

MIC 2.5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 13 Activity

Activity

MIC
Antiparasitic
40 µM

Target

P. putida ATCC 12633

Source & Reference

DRAMP

Other

C 33148) (MIC 5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activity (MLC): B. subtilis ATCC 6633 (ML
Evidence 14 Activity

Activity

MIC
Antiviral
2.5 µM

Target

S. iniae F-8502

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 2.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 2.5 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harve
Evidence 15 Activity

Activity

MIC
Antiviral
2.5 µM

Target

V. anguillarum ATCC 19264

Source & Reference

DRAMP

Other

inst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 10 uM), S. iniae F-8502 (MIC 2.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 2.5 uM), Vibriopenaeicida KHA (MIC 10 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 2.5 uM), V. vul
Evidence 16 Activity

Activity

MIC
Antiviral
10 µM

Target

A. salmonicida NCMB 1102

Source & Reference

DRAMP

Other

MIC 2.5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 17 Activity

Activity

MIC
Antiviral
40 µM

Target

P. putida ATCC 12633

Source & Reference

DRAMP

Other

C 33148) (MIC 5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 10 uM), P. putida ATCC 12633 (MIC 40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activity (MLC): B. subtilis ATCC 6633 (ML
Evidence 18 Activity

Activity

% Hemolysis
Hemolysis
10 80 %
[Ref.12581207]10% hemolytic activity at 0.25 µM, 80% hemolytic activity at 1 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Eur J Biochem. 2003 Feb 270(4):675-686.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
1 µM
Hemolytic Cytotoxic
50% Hemolysis | 1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major. | Eur J Biochem | 2003
Evidence 20 Activity

Activity

100% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
100% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major. | Eur J Biochem | 2003
Evidence 21 Activity

Activity

EC50
Toxicity
4.6 µM
Cytotoxic
EC50 | 4.6 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream. | Biochemistry | 2007
Evidence 22 Activity

Activity

EC50
Toxicity
8.5 µM
Cytotoxic
EC50 | 8.5 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream. | Biochemistry | 2007
Evidence 23 Activity

Activity

EC50
Toxicity
4.8 µM
Cytotoxic
EC50 | 4.8 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream. | Biochemistry | 2007
Evidence 24 Activity

Activity

EC50
Toxicity
9.6 µM
Cytotoxic
EC50 | 9.6 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream. | Biochemistry | 2007
Evidence 25 Activity

Activity

80% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
80% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of GXXXXG motif in Chrysophsin-1 and its implication in the design of analogs with cell-selective antimicrobial and anti-endotoxin activities. | Sci Rep | 2017
Evidence 26 Activity

Activity

95% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
95% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of GXXXXG motif in Chrysophsin-1 and its implication in the design of analogs with cell-selective antimicrobial and anti-endotoxin activities. | Sci Rep | 2017
Evidence 27 Activity

Activity

100% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
100% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of GXXXXG motif in Chrysophsin-1 and its implication in the design of analogs with cell-selective antimicrobial and anti-endotoxin activities. | Sci Rep | 2017
Evidence 28 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.12581207]10% hemolytic activity at 0.25 µM, 80% hemolytic activity at 1 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2003 Feb 270(4):675-686.
Evidence 29 Hemolysis

Activity

10 80 %
% Hemolysis
[Ref.12581207]10% hemolytic activity at 0.25 µM, 80% hemolytic activity at 1 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Eur J Biochem. 2003 Feb 270(4):675-686.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.