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Peptide record

TPDB05245

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB05245
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKIFKKIEKVGRNIRNGIIKAGPAVAVLGEAKAL
Physicochemical Analysis
C177H303N51O42
DCQHMSTY
K
3817.67
11.23
9
2
17
+7
7.63
0.003
117.14
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
144.07
2
Residue Composition
number
5
A
2
R
2
N
0
D
0
C
2
E
0
Q
4
G
0
H
5
I
2
L
7
K
0
M
1
F
1
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 2 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 5 L: 2 K: 7 M: 0 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
35
C177H303N51O42
3817.67
11.23
+7
7.63
0.003
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Lethal concentrations against E. coli D21 or D31 (0.0.30-0.36 uM), S. marsescens Strain 12 (2.6 uM), P. aeruginosa (2.98uM), B. subtilis (17 uM), B. megaterium (0.64 uM), B.thuringiensis (>88 uM), S.fecalis (>88 uM), and M. luteus (0.29 uM). UPdated 10/2020
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Lethal concentrations against E. coli D21 or D31 (0.0.30-0.36 uM), S. marsescens Strain 12 (2.6 uM), P. aeruginosa (2.98uM), B. subtilis (17 uM), B. megaterium (0.64 uM), B.thuringiensis (>88 uM), S.fecalis (>88 uM), and M. luteus (0.29 uM). UPdated 10/2020
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Lethal concentrations against E. coli D21 or D31 (0.0.30-0.36 uM), S. marsescens Strain 12 (2.6 uM), P. aeruginosa (2.98uM), B. subtilis (17 uM), B. megaterium (0.64 uM), B.thuringiensis (>88 uM), S.fecalis (>88 uM), and M. luteus (0.29 uM). UPdated 10/2020
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
0% Hemolysis | 200 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A novel cecropin B-derived peptide with antibacterial and potential anti-inflammatory properties. | PeerJ | 2018