TPDB

3D PDB MODEL

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TPDB ID TPDB05243

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 29-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

GLPVCGETCVGGTCNYPGCTCSWPVCTRN

FASTA

>TPDB05243|Antibacterial;Anticancer;Toxicity|length=29
GLPVCGETCVGGTCNYPGCTCSWPVCTRN

Formula C122H189N35O40S6

Absent Amino Acids ADQHIKMF

Common Amino Acids C

Mass 2978.41

PI 5.90

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 6

Net Charge -0

Boman Index 1.18

Hydrophobicity 0.131

Aliphatic Index 43.45

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7365

Absorbance 280nm 247.28

Polar Residues 14

number

0

A

1

R

2

N

0

D

6

C

1

E

0

Q

5

G

0

H

0

I

1

L

0

K

0

M

0

F

3

P

1

S

4

T

1

W

1

Y

3

V

Amino Acid Distribution

A: 0 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 5 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 3 S: 1 T: 4 W: 1 Y: 1 V: 3

Length

29

Formula

C122H189N35O40S6

Mass

2978.41

PI

5.90

Net Charge

-0

Boman Index

1.18

Hydrophobicity

0.131

Evidence 1 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014

Evidence 2 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Human PBMC

Target

Target Cell Human PBMC

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

- | NA | target cell: Human foreskin fibroblasts (HFF)

Target

Target Cell Human foreskin fibroblasts (HFF)

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting | Chembiochem | 2014

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes: Not active up to 50 µM | Cytotoxicity: HFF-1: Not active up to 60 µM PBMCs: Not active up to 60 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Chembiochem. 2014 Sep 5 15(13):1956-65.