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Peptide record

TPDB05237

Temporin L Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB05237
Temporin L
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP DRAVP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FVQWFSKFLGRIL
Physicochemical Analysis
C83H121N19O16
ANDCEHMPTY
F
1640.99
11.49
2
0
8
+2
-4.08
0.823
112.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
335.16
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
1
I
2
L
1
K
0
M
3
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 2 K: 1 M: 0 F: 3 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C83H121N19O16
1640.99
11.49
+2
-4.08
0.823
Free
L
Not Available
Free
Antibacterial
European common frog,Rana temporaria
Evidence Records 16 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against B. megaterium and E. coli (ref for AP00095). Active against parasites L. mexicana (Molecules. 2015 Feb 6 20(2):2775-85).
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
1996

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 3 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against B. megaterium and E. coli (ref for AP00095). Active against parasites L. mexicana (Molecules. 2015 Feb 6 20(2):2775-85).
Evidence 4 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against B. megaterium and E. coli (ref for AP00095). Active against parasites L. mexicana (Molecules. 2015 Feb 6 20(2):2775-85).
Evidence 5 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against B. megaterium and E. coli (ref for AP00095). Active against parasites L. mexicana (Molecules. 2015 Feb 6 20(2):2775-85).
Evidence 6 Activity

Activity

94% Hemolysis
Toxicity
24 µM
Hemolytic Cytotoxic
94% Hemolysis | 24 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship, conformational and biological studies of temporin L analogues. | J Med Chem | 2011
Evidence 7 Activity

Activity

92% Hemolysis
Toxicity
12 µM
Hemolytic Cytotoxic
92% Hemolysis | 12 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship, conformational and biological studies of temporin L analogues. | J Med Chem | 2011
Evidence 8 Activity

Activity

48% Hemolysis
Toxicity
6 µM
Hemolytic Cytotoxic
48% Hemolysis | 6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship, conformational and biological studies of temporin L analogues. | J Med Chem | 2011
Evidence 9 Activity

Activity

13% Hemolysis
Toxicity
3 µM
Hemolytic Cytotoxic
13% Hemolysis | 3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship, conformational and biological studies of temporin L analogues. | J Med Chem | 2011
Evidence 10 Activity

Activity

3% Hemolysis
Toxicity
1.5 µM
Hemolytic Cytotoxic
3% Hemolysis | 1.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship, conformational and biological studies of temporin L analogues. | J Med Chem | 2011
Evidence 11 Activity

Activity

100% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
100% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Noncytotoxic Temporin L Analogue with In Vivo Antibacterial and Antiendotoxin Activities and a Nonmembrane-Lytic Mode of Action | ACS Infect Dis | 2020
Evidence 12 Activity

Activity

LC
Toxicity
40 µM
Cytotoxic
LC | 40 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
A Noncytotoxic Temporin L Analogue with In Vivo Antibacterial and Antiendotoxin Activities and a Nonmembrane-Lytic Mode of Action | ACS Infect Dis | 2020
Evidence 13 Activity

Activity

50% Cytotoxicity
Toxicity
18.75 µM
Cytotoxic
50% Cytotoxicity | 18.75 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Broad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Int J Mol Sci | 2022
Evidence 14 Activity

Activity

83% Hemolysis
Toxicity
24 µM
Hemolytic Cytotoxic
83% Hemolysis | 24 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Modulation of anti-endotoxin property of Temporin L by minor amino acid substitution in identified phenylalanine zipper sequence. | Biochem J | 2016
Evidence 15 Activity

Activity

50% Cytotoxicity
Toxicity
24 µM
Cytotoxic
50% Cytotoxicity | 24 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Modulation of anti-endotoxin property of Temporin L by minor amino acid substitution in identified phenylalanine zipper sequence. | Biochem J | 2016
Evidence 16 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.