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Peptide record

TPDB05227

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB05227
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb AI4AVP AVPpred-BWR dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFGVLGSIAKHVLPHVVPVIAEKL
Physicochemical Analysis
C124H205N31O29
RNDCQMTWY
V
2594.18
9.88
4
1
14
+1
3.00
1.148
159.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
3
G
2
H
2
I
4
L
2
K
0
M
1
F
2
P
1
S
0
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 2 I: 2 L: 4 K: 2 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 5
Chemical Descriptors
25
C124H205N31O29
2594.18
9.88
+1
3.00
1.148
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
20 µM
Cytotoxic
50% Cell death | 20 | µM | target cell: CD4+ T Lymphocytes

Target

CD4+ T Lymphocytes

Source & Reference

NA
DBAASP
Inhibition of HIV Infection by Caerin 1 Antimicrobial Peptides | Peptides | 2015
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.26026377]CD4+ T Lymphocytes:50% cell death at 20 µM.

Source & Reference

NA
DRAMP
Peptides. 2015 Sep 71:296-303. ##J Virol. 2005 Sep 79(18):11598-606. ##Peptides. 2004 Jun 25(6):1035-1054.##J Pept Res. 1998 Feb 51(2):121-126.