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Peptide record

TPDB05214

Antibacterial Antifungal Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05214

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLNALKNFAKTAGKRLKSLLN

FASTA

>TPDB05214|Antibacterial;Antifungal;Toxicity|length=21
FLNALKNFAKTAGKRLKSLLN

Formula C108H183N31O27

Absent Amino Acids DCEQHIMPWYV

Common Amino Acids L

Mass 2347.83

PI 11.80

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +5

Boman Index 0.74

Hydrophobicity -0.119

Aliphatic Index 107.14

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 5

number

Amino Acid Distribution

A: 3 R: 1 N: 3 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 5 K: 4 M: 0 F: 2 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0

Length

Formula

C108H183N31O27

Mass

2347.83

11.80

Net Charge

Boman Index

0.74

Hydrophobicity

-0.119

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.4 µM

Target

Target Organism Escherichia coli HP101BA 7601c

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli HP101BA 7601c (MIC 6.4 uM), K. pneumonia PTCC1388 (MIC 7.3 uM), M. luteus PTCC1625 (MIC 4.7 uM), and S. aureus PTCC1

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7.3 µM

Target

Target Organism K. pneumonia PTCC1388

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli HP101BA 7601c (MIC 6.4 uM), K. pneumonia PTCC1388 (MIC 7.3 uM), M. luteus PTCC1625 (MIC 4.7 uM), and S. aureus PTCC1431 (MIC 5.3 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.7 µM

Target

Target Organism M. luteus PTCC1625

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli HP101BA 7601c (MIC 6.4 uM), K. pneumonia PTCC1388 (MIC 7.3 uM), M. luteus PTCC1625 (MIC 4.7 uM), and S. aureus PTCC1431 (MIC 5.3 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 5.3 µM

Target

Target Organism Staphylococcus aureus PTCC1431

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

1c (MIC 6.4 uM), K. pneumonia PTCC1388 (MIC 7.3 uM), M. luteus PTCC1625 (MIC 4.7 uM), and S. aureus PTCC1431 (MIC 5.3 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.4 µM

Target

Target Organism Escherichia coli HP101BA 7601c

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli HP101BA 7601c (MIC 6.4 uM), K. pneumonia PTCC1388 (MIC 7.3 uM), M. luteus PTCC1625 (MIC 4.7 uM), and S. aureus PTCC1

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7.3 µM

Target

Target Organism K. pneumonia PTCC1388

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E. coli HP101BA 7601c (MIC 6.4 uM), K. pneumonia PTCC1388 (MIC 7.3 uM), M. luteus PTCC1625 (MIC 4.7 uM), and S. aureus PTCC1431 (MIC 5.3 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.7 µM

Target

Target Organism M. luteus PTCC1625

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against E. coli HP101BA 7601c (MIC 6.4 uM), K. pneumonia PTCC1388 (MIC 7.3 uM), M. luteus PTCC1625 (MIC 4.7 uM), and S. aureus PTCC1431 (MIC 5.3 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 5.3 µM

Target

Target Organism Staphylococcus aureus PTCC1431

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

1c (MIC 6.4 uM), K. pneumonia PTCC1388 (MIC 7.3 uM), M. luteus PTCC1625 (MIC 4.7 uM), and S. aureus PTCC1431 (MIC 5.3 uM).

Evidence 9 Activity

Activity

Activity Endpoint 3% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 60 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3% Hemolysis | 60 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Identification and characterization of novel antibacterial peptides from skin secretions of Euphlyctis cyanophlyctis. | Int J Pept Res Ther | 2012

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.Int J Pept Res Ther(2012)18 107.]<3% hemolytic activity at 60 µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Int. J. Pept. Res. Ther. 2012 18:107-115.