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Peptide record

TPDB05205

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB05205
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia dbACP Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLDTLKGAAKNVVGSLASKVMEKL
Physicochemical Analysis
C112H200N30O34S1
RCQHIFPWY
L
2543.06
10.16
4
2
12
+2
4.73
0.372
124.80
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
3
A
0
R
1
N
1
D
0
C
1
E
0
Q
3
G
0
H
0
I
5
L
4
K
1
M
0
F
0
P
2
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 5 K: 4 M: 1 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
25
C112H200N30O34S1
2543.06
10.16
+2
4.73
0.372
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 (MIC 25 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pn
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 (MIC 25 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. a
Evidence 3 Activity

Activity

MIC
Antibacterial
100 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP

Other

5 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: ki
Evidence 4 Activity

Activity

MIC
Antibacterial
100 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: killed the murine melanoma cell line B16F
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP

Other

(MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: killed the murine melanoma cell line B16F10 (IC50 25.7 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 (MIC 25 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pn
Evidence 7 Activity

Activity

MIC
Antifungal
50 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 25 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. a
Evidence 8 Activity

Activity

MIC
Antifungal
100 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: ki
Evidence 9 Activity

Activity

MIC
Antifungal
100 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: killed the murine melanoma cell line B16F
Evidence 10 Activity

Activity

MIC
Antifungal
100 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: killed the murine melanoma cell line B16F10 (IC50 25.7 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25922 (MIC 25 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pn
Evidence 12 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25922 (MIC 25 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. a
Evidence 13 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

DRAMP

Other

5 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: ki
Evidence 14 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: killed the murine melanoma cell line B16F
Evidence 15 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

DRAMP

Other

(MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: killed the murine melanoma cell line B16F10 (IC50 25.7 uM).
Evidence 16 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli ATCC 25922 (MIC 25 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pn
Evidence 17 Activity

Activity

MIC
Antiviral
50 µM

Target

Enterobacter cloacae HNTCC 53001

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25922 (MIC 25 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. a
Evidence 18 Activity

Activity

MIC
Antiviral
100 µM

Target

Klebsiella pneumoniae KK3 9904

Source & Reference

DRAMP

Other

5 uM), E. cloacae HNTCC 53001 (MIC 50 uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: ki
Evidence 19 Activity

Activity

MIC
Antiviral
100 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

uM), Streptococcus Group B HNTCC 80130 (MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: killed the murine melanoma cell line B16F
Evidence 20 Activity

Activity

MIC
Antiviral
100 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

DRAMP

Other

(MIC 50 uM), K. pneumoniae KK3 9904 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 100 uM), S. epidermidis RP62A (MIC 100 uM). Anticancer: killed the murine melanoma cell line B16F10 (IC50 25.7 uM).
Evidence 21 Activity

Activity

50% Hemolysis
Toxicity
>400 µM
Hemolytic Cytotoxic
50% Hemolysis | >400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Pentadactylin: an antimicrobial peptide from the skin secretions of the South American bullfrog Leptodactylus pentadactylus. | Comp Biochem Physiol C Toxicol Pharmacol | 2005
Evidence 22 Activity

Activity

IC50
Toxicity
35.9 µM
Cytotoxic
IC50 | 35.9 | µM | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Anti-proliferative and cytotoxic activity of pentadactylin isolated from Leptodactylus labyrinthicus on melanoma cells. | Amino Acids | 2011