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Peptide record

TPDB05203

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB05203
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
AntiBP3 Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept AI4AVP dbAMP 3.0 DRAMP DRAVP 2.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
GIPCGESCVFIPCITSVAGCSCKSKVCYRN
Physicochemical Analysis
C131H214N36O40S6
DQHLMW
C
3125.72
8.02
3
1
9
+2
2.42
0.560
71.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
59.67
13
Residue Composition
number
1
A
1
R
1
N
0
D
6
C
1
E
0
Q
3
G
0
H
3
I
0
L
2
K
0
M
1
F
2
P
4
S
1
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 0 K: 2 M: 0 F: 1 P: 2 S: 4 T: 1 W: 0 Y: 1 V: 3
Chemical Descriptors
30
C131H214N36O40S6
3125.72
8.02
+2
2.42
0.560
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 48 to 247 nM, depending upon the particular virus strain and host cell line (e.g., HIV-1 strain IIIB/CEM-SS cell (EC50 73 nM), H1122 strain/MT-2 cell (EC50 48 nM), and A17 strain/MT-2 (EC50 247 nM). More data in Table 1 of the paper. Updated 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

DRAMP Antifungipept

Other

Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 48 to 247 nM, depending upon the particular virus strain and host cell line (e.g., HIV-1 strain IIIB/CEM-SS cell (EC50 73 nM), H1122 strain/MT-2 cell (EC50 48 nM), and A17 strain/MT-2 (EC50 247 nM). More data in Table 1 of the paper. Updated 7/2021
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 48 to 247 nM, depending upon the particular virus strain and host cell line (e.g., HIV-1 strain IIIB/CEM-SS cell (EC50 73 nM), H1122 strain/MT-2 cell (EC50 48 nM), and A17 strain/MT-2 (EC50 247 nM). More data in Table 1 of the paper. Updated 7/2021
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Circulins C-F showed anti HIV-1 effect with EC50 values (concentration for 50% inhibition) in the range from 48 to 247 nM, depending upon the particular virus strain and host cell line (e.g., HIV-1 strain IIIB/CEM-SS cell (EC50 73 nM), H1122 strain/MT-2 cell (EC50 48 nM), and A17 strain/MT-2 (EC50 247 nM). More data in Table 1 of the paper. Updated 7/2021