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Peptide record

TPDB05202

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB05202
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAMP DRAVP 2.0 APD_complete Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
GLPTCGETCFGGTCNTPGCTCDPWPVCTHN
Physicochemical Analysis
C126H187N35O43S6
ARQIKMSY
CT
3072.44
4.06
1
2
4
-2
2.83
-0.163
22.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5875
191.22
14
Residue Composition
number
0
A
0
R
2
N
1
D
6
C
1
E
0
Q
5
G
1
H
0
I
1
L
0
K
0
M
1
F
4
P
0
S
6
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 5 H: 1 I: 0 L: 1 K: 0 M: 0 F: 1 P: 4 S: 0 T: 6 W: 1 Y: 0 V: 1
Chemical Descriptors
30
C126H187N35O43S6
3072.44
4.06
-2
2.83
-0.163
Evidence Records 9 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 308 nM) and cytotoxicity (TC50 6.2 uM), therapeutic index (~20) (Ireland et al., 2008) .
Evidence 2 Activity

Activity

Antifungal

Source & Reference

DRAMP CAFPdb Antifungipept

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 308 nM) and cytotoxicity (TC50 6.2 uM), therapeutic index (~20) (Ireland et al., 2008) .
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 308 nM) and cytotoxicity (TC50 6.2 uM), therapeutic index (~20) (Ireland et al., 2008) .
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 308 nM) and cytotoxicity (TC50 6.2 uM), therapeutic index (~20) (Ireland et al., 2008) .
Evidence 5 Activity

Activity

% Hemolysis
Hemolysis
75 %
[Ref:16872274] It has 75% hemolytic activity at 25.0 µM against human type A red blood cells.

Target

human type A red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

75% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
75% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A novel suite of cyclotides from Viola odorata: sequence variation and the implications for structure, function and stability. | Biochem J | 2006
Evidence 7 Activity

Activity

IC50
Toxicity
6.17 µM
Cytotoxic
IC50 | 6.17 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Cyclotides as natural anti-HIV agents | Biopolymers | 2008
Evidence 8 Activity

Activity

IC50
Toxicity
6170 nM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref:16872274] It has 75% hemolytic activity at 25.0 µM against human type A red blood cells. | Cytotoxicity: [Ref.18008336]CEM-SS cells:IC50=6170 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.
Evidence 9 Hemolysis

Activity

75 %
% Hemolysis
[Ref:16872274] It has 75% hemolytic activity at 25.0 µM against human type A red blood cells.
Hemolysis

Target

human type A red blood cells

Source & Reference

APD_complete PD_Hemolysis
Biochem J. 2006 Nov 15 400(1):1-12.##Biopolymers. 2008 90(1):51-60.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.