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Peptide record

TPDB05199

Caerin 1.10 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB05199
Caerin 1.10
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLSVLGSVAKHVLPHVVPVIAEKL
Physicochemical Analysis
C121H207N31O30
RNDCQMFTWY
V
2576.16
9.88
4
1
14
+1
4.07
1.160
171.20
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
2
G
2
H
1
I
5
L
2
K
0
M
0
F
2
P
2
S
0
T
0
W
0
Y
6
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 1 L: 5 K: 2 M: 0 F: 0 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 6
Chemical Descriptors
25
C121H207N31O30
2576.16
9.88
+1
4.07
1.160
Free
L
Not Available
Free
Anticancer
Magnificent treefrog Litoria splendida, Australia
Evidence Records 3 records
Evidence 1 Activity

Activity

Not Available
Anticancer

Target

Lung Cancer
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2000

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 2 Activity

Activity

50% Cell death
Toxicity
22 µM
Cytotoxic
50% Cell death | 22 | µM | target cell: CD4+ T Lymphocytes

Target

CD4+ T Lymphocytes

Source & Reference

NA
DBAASP
Inhibition of HIV Infection by Caerin 1 Antimicrobial Peptides | Peptides | 2015
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.26026377]CD4+ T Lymphocytes:50% cell death at 22 µM.

Source & Reference

NA
DRAMP
Peptides. 2015 Sep 71:296-303. ##Rapid Commun Mass Spectrom. 2005 19(18):2716-2724.##Eur J Biochem. 2000 Jan 267(1):269-275.