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Peptide record

TPDB05189

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB05189
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFGKILGVGKKVLCGLSGMC
Physicochemical Analysis
C93H162N24O23S3
ARNDEQHPTWY
G
2080.64
9.80
3
0
9
+3
-1.09
1.090
120.48
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
6.01
3
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
6
G
0
H
1
I
4
L
3
K
1
M
1
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 1 L: 4 K: 3 M: 1 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
21
C93H162N24O23S3
2080.64
9.80
+3
-1.09
1.090
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Activity against microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

dbAMP DRAMP

Other

Activity against microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

ainst microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Activity against microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Activity against microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
50 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Activity against microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 8 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

DRAMP

Other

Activity against microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Candida albicans ATCC 90028

Source & Reference

DRAMP

Other

ainst microorganisms E. coli ATCC 25922 (MIC 3 uM), S. aureus NCTC 8325 (MIC 12.5 uM) and C. albicans ATCC 90028 (MIC 50 uM).
Evidence 10 Activity

Activity

LC50
Hemolysis
40 µM
[Ref:16621155] LC50=40 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Peptides. 2006 Sep 27(9):2111-2117.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
50% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami. | Peptides | 2006
Evidence 12 Activity

Activity

LC50
Toxicity
40 µM
Hemolytic
Hemolytic_activity: [Ref:16621155] LC50=40 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2006 Sep 27(9):2111-2117.
Evidence 13 Hemolysis

Activity

40 µM
LC50
[Ref:16621155] LC50=40 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Peptides. 2006 Sep 27(9):2111-2117.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.