TPDB

3D PDB MODEL

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TPDB ID TPDB05177

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP Peptipedia AFP-GFuse Antifp Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GLGSLVGNALRIGAKLL

FASTA

>TPDB05177|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=17
GLGSLVGNALRIGAKLL

Formula C74H134N22O20

Absent Amino Acids DCEQHMFPTWY

Common Amino Acids L

Mass 1652.01

PI 11.49

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +2

Boman Index -0.99

Hydrophobicity 1.000

Aliphatic Index 166.47

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

2

A

1

R

1

N

0

D

0

C

0

E

0

Q

4

G

0

H

1

I

5

L

1

K

0

M

0

F

0

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 5 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

17

Formula

C74H134N22O20

Mass

1652.01

PI

11.49

Net Charge

+2

Boman Index

-0.99

Hydrophobicity

1.000

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 12.5 uM). Updated 5/2019.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 12.5 uM). Updated 5/2019.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 12.5 uM). Updated 5/2019.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP Antifungipept

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 12.5 uM). Updated 5/2019.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 12.5 uM). Updated 5/2019.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 50 uM) and S. aureus (MIC 12.5 uM). Updated 5/2019.