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Peptide record

TPDB05165

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB05165
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept AI4AVP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GIPCGESCVWIPCITSAIGCSCKSKVCYRN
Physicochemical Analysis
C134H217N37O40S6
DQHLMF
C
3178.78
8.02
3
1
9
+2
1.32
0.447
74.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
231.69
13
Residue Composition
number
1
A
1
R
1
N
0
D
6
C
1
E
0
Q
3
G
0
H
4
I
0
L
2
K
0
M
0
F
2
P
4
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 4 L: 0 K: 2 M: 0 F: 0 P: 2 S: 4 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
30
C134H217N37O40S6
3178.78
8.02
+2
1.32
0.447
Evidence Records 4 records
Evidence 1 Activity

Activity

HD50
Hemolysis
8.91 µM
[Ref.20580652] HD50=8.91 µM against human type O red blood cells.

Target

human type O red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Phytochemistry. 2008 Feb 69(4):939-952.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
8.91 µM
Hemolytic Cytotoxic
50% Hemolysis | 8.91 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation and characterization of cytotoxic cyclotides from Viola tricolor. | Peptides | 2010
Evidence 3 Activity

Activity

HD50
Toxicity
8.91 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.20580652] HD50=8.91 µM against human type O red blood cells. | Cytotoxicity: [Ref.14987049] Cytotoxicity: U-937 GTB (lymphoma)(IC50 = 0.6 µM) and RPMI-8226/s (myeloma)(IC50 = 1 µM).##[Ref.20580652] Cytotoxicity: U251(IC50 = 6.03 µg/mL), MDA-MB-231(IC50 = 3.69 µg/mL), A549(IC50 = 3.90 µg/mL), DU145(IC50 = 3.07 µg/mL), BEL-7402(IC50 = 4.94 µg/mL).

Target

erythrocytes

Source & Reference

NA
DRAMP
Phytochemistry. 2008 Feb 69(4):939-952.
Evidence 4 Hemolysis

Activity

8.91 µM
HD50
[Ref.20580652] HD50=8.91 µM against human type O red blood cells.
Hemolysis

Target

human type O red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Phytochemistry. 2008 Feb 69(4):939-952.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.