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Peptide record

TPDB05162

Buforin 2 Buforin-II BUF2 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05162
Buforin 2 Buforin-II BUF2
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept CAFPdb AI4AVP AVPpred-BWR dbAMP 3.0 DRAVP 2.0 CellPPD-MOD CPPsite3.0 PerseuCPP ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
TRSSRAGLQFPVGRVHRLLRK
Physicochemical Analysis
C106H184N40O26
NDCEIMWY
R
2434.88
13.00
7
0
7
+6
4.61
-0.638
88.10
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
1
Q
2
G
1
H
0
I
3
L
1
K
0
M
1
F
1
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 3 K: 1 M: 0 F: 1 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
21
C106H184N40O26
2434.88
13.00
+6
4.61
-0.638
Free
L
Cationic and amphipathic
Linear
Linear
Free
Antimicrobial
Bufo Bufo Gargarizans
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 48 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bac
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. mutans

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/m
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

S. pneumoniae

Source & Reference

dbAMP DRAMP

Other

am+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

P. putida

Source & Reference

dbAMP DRAMP

Other

2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

utans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml
Evidence 7 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml)
Evidence 8 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

ia E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its de
Evidence 9 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP

Other

. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its derivative buforin IIb (sequenc
Evidence 10 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

atia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed
Evidence 11 Activity

Activity

IC50
IC50 =90-95 µg/ml
Anticancer
90-95 µg/mL

Target

Lymphoma Cancer
U-937
Blood

Assay & Model

MTT/MTS assay
Not Available

Source & Reference

dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2011

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 12 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida
Evidence 13 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bac
Evidence 14 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. mutans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/m
Evidence 15 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

S. pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

am+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/
Evidence 16 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

P. putida

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4
Evidence 17 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

utans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml
Evidence 18 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml)
Evidence 19 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ia E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its de
Evidence 20 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

C. neoformans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its derivative buforin IIb (sequenc
Evidence 21 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

atia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed
Evidence 22 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida
Evidence 23 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bac
Evidence 24 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

S. mutans

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/m
Evidence 25 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

S. pneumoniae

Source & Reference

dbAMP 3.0 DRAMP

Other

am+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/
Evidence 26 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

P. putida

Source & Reference

dbAMP 3.0 DRAMP

Other

2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4
Evidence 27 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

utans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml
Evidence 28 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP 3.0 DRAMP

Other

pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml)
Evidence 29 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

ia E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its de
Evidence 30 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

C. neoformans

Source & Reference

dbAMP 3.0 DRAMP

Other

. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its derivative buforin IIb (sequenc
Evidence 31 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

atia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed
Evidence 32 Activity

Activity

MIC
Antiviral
2 µg/mL

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida
Evidence 33 Activity

Activity

MIC
Antiviral
4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bac
Evidence 34 Activity

Activity

MIC
Antiviral
2 µg/mL

Target

S. mutans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/m
Evidence 35 Activity

Activity

MIC
Antiviral
4 µg/mL

Target

S. pneumoniae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

am+ bacteria B. subtilis (MIC 2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/
Evidence 36 Activity

Activity

MIC
Antiviral
2 µg/mL

Target

P. putida

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

2 ug/ml), S. aureus (MIC 4 ug/ml), S. mutans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4
Evidence 37 Activity

Activity

MIC
Antiviral
4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

utans (MIC 2 ug/ml), S. pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml
Evidence 38 Activity

Activity

MIC
Antiviral
1 µg/mL

Target

S. typhimurium

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

pneumoniae (MIC 4 ug/ml), P. putida (MIC 2 ug/ml), Gram- bacteria E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml)
Evidence 39 Activity

Activity

MIC
Antiviral
1 µg/mL

Target

Candida albicans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ia E. coli (MIC 4 ug/ml), S. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its de
Evidence 40 Activity

Activity

MIC
Antiviral
1 µg/mL

Target

C. neoformans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

. typhimurium (MIC 1 ug/ml), Serratia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its derivative buforin IIb (sequenc
Evidence 41 Activity

Activity

MIC
Antiviral
1 µg/mL

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

atia sp. (MIC 4 ug/ml), fungi C. albicans (MIC 1 ug/ml), C. neoformans (MIC 1 ug/ml), and S. cerevisiae (MIC 1 ug/ml). Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed
Evidence 42 Activity

Activity

Cell-penetrating Peptides

Target

Ai9 Tdtomato Npcs

Assay & Model

Ai9 or wild-type mice
Ai9 or wild-type mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
SpyCas9 RNPs
In vitro and in vivo
CCSSCCSSCCSCCSSSSSSCSCCCSCCCCCHHHHCCCSCC
Evidence 43 Activity

Activity

Cell-penetrating Peptides

Target

THP-1 Cells and E. coli

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphipathic
Protein derived
FITC-Magnetite nanoparticles
Cytosol
In vitro
CCCSSSTTCCCTTTTC
Evidence 44 Activity

Activity

50% Cell death
Toxicity
>41.1 µM
Cytotoxic
50% Cell death | >41.1 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010
Evidence 45 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Human monocytes

Target

Human monocytes

Source & Reference

NA
DBAASP
Unveiling the Multifaceted Mechanisms of Antibacterial Activity of Buforin II and Frenatin 2.3S Peptides from Skin Micro-Organs of the Orinoco Lime Treefrog (Sphaenorhynchus lacteus). | Int J Mol Sci | 2018
Evidence 46 Activity

Activity

<10% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
<10% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Unveiling the Multifaceted Mechanisms of Antibacterial Activity of Buforin II and Frenatin 2.3S Peptides from Skin Micro-Organs of the Orinoco Lime Treefrog (Sphaenorhynchus lacteus). | Int J Mol Sci | 2018
Evidence 47 Activity

Activity

IC50
Toxicity
>=65 µM
Cytotoxic
IC50 | >=65 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 48 Activity

Activity

50% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and protease stability of peptides containing fluorinated amino acids | J Am Chem Soc | 2007
Additional Detail Fields 1 fields
CCSSCCSSCCSCCSSSSSSCSCCCSCCCCCHHHHCCCSCC CCCSSSTTCCCTTTTC