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Peptide record

TPDB05158

Antibacterial Anticancer Antifungal Antiparasitic standard
46 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05158
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIFSKLAGKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC
Physicochemical Analysis
C212H371N59O60S3
QHPWY
GK
4802.82
10.11
9
4
18
+5
10.55
0.220
114.35
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
2.60
7
Residue Composition
number
2
A
1
R
2
N
2
D
2
C
2
E
0
Q
8
G
0
H
6
I
4
L
8
K
1
M
1
F
0
P
2
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 2 C: 2 E: 2 Q: 0 G: 8 H: 0 I: 6 L: 4 K: 8 M: 1 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
46
C212H371N59O60S3
4802.82
10.11
+5
10.55
0.220
Evidence Records 45 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.2 µM

Target

Escherichia coli D21

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syri
Evidence 2 Activity

Activity

MIC
Antibacterial
0.7 µM

Target

Pseudomonas aeruginosa ATCC 15692

Source & Reference

dbAMP DRAMP

Other

Active against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglome
Evidence 3 Activity

Activity

MIC
Antibacterial
0.1 µM

Target

Y. pseudotuberculosis YPIII

Source & Reference

dbAMP DRAMP

Other

e against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B.
Evidence 4 Activity

Activity

MIC
Antibacterial
0.2 µM

Target

P. syringae pv tabaci

Source & Reference

dbAMP DRAMP

Other

0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. au
Evidence 5 Activity

Activity

MIC
Antibacterial
0.4 µM

Target

E. agglomerans Bo-1S

Source & Reference

dbAMP DRAMP

Other

IC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fung
Evidence 6 Activity

Activity

MIC
Antibacterial
0.1 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP

Other

M), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Als
Evidence 7 Activity

Activity

MIC
Antibacterial
0.4 µM

Target

Staphylococcus aureus Cowan I

Source & Reference

dbAMP DRAMP

Other

2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC
Evidence 8 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

Candida albicans clinical isolate

Source & Reference

dbAMP DRAMP

Other

Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC
Evidence 9 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

V. harveyi ATCC33866

Source & Reference

dbAMP DRAMP

Other

I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C.
Evidence 10 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

V. alginolyticus ATCC17749

Source & Reference

dbAMP DRAMP

Other

s clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fe
Evidence 11 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

V. anguillarum ATCC19264

Source & Reference

dbAMP DRAMP

Other

e against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC
Evidence 12 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Citrobacter freundii ATCC43864

Source & Reference

dbAMP DRAMP

Other

l), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC1
Evidence 13 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

S. fexneri

Source & Reference

dbAMP DRAMP

Other

g/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see th
Evidence 14 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

S. saprophyticus

Source & Reference

dbAMP DRAMP

Other

9264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see the 2024 ref above).
Evidence 15 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

L. monocytogenes ATCC19115

Source & Reference

dbAMP DRAMP

Other

43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see the 2024 ref above).
Evidence 16 Activity

Activity

MIC
Antifungal
0.2 µM

Target

Escherichia coli D21

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syri
Evidence 17 Activity

Activity

MIC
Antifungal
0.7 µM

Target

Pseudomonas aeruginosa ATCC 15692

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglome
Evidence 18 Activity

Activity

MIC
Antifungal
0.1 µM

Target

Y. pseudotuberculosis YPIII

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

e against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B.
Evidence 19 Activity

Activity

MIC
Antifungal
0.2 µM

Target

P. syringae pv tabaci

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. au
Evidence 20 Activity

Activity

MIC
Antifungal
0.4 µM

Target

E. agglomerans Bo-1S

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fung
Evidence 21 Activity

Activity

MIC
Antifungal
0.1 µM

Target

B. megaterium Bm11

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Als
Evidence 22 Activity

Activity

MIC
Antifungal
0.4 µM

Target

Staphylococcus aureus Cowan I

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC
Evidence 23 Activity

Activity

MIC
Antifungal
0.5 µM

Target

Candida albicans clinical isolate

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC
Evidence 24 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

V. harveyi ATCC33866

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C.
Evidence 25 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

V. alginolyticus ATCC17749

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

s clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fe
Evidence 26 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

V. anguillarum ATCC19264

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

e against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC
Evidence 27 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Citrobacter freundii ATCC43864

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

l), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC1
Evidence 28 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

S. fexneri

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

g/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see th
Evidence 29 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

S. saprophyticus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

9264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see the 2024 ref above).
Evidence 30 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

L. monocytogenes ATCC19115

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see the 2024 ref above).
Evidence 31 Activity

Activity

MIC
Antiparasitic
0.2 µM

Target

Escherichia coli D21

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syri
Evidence 32 Activity

Activity

MIC
Antiparasitic
0.7 µM

Target

Pseudomonas aeruginosa ATCC 15692

Source & Reference

DRAMP

Other

Active against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglome
Evidence 33 Activity

Activity

MIC
Antiparasitic
0.1 µM

Target

Y. pseudotuberculosis YPIII

Source & Reference

DRAMP

Other

e against Gram- bacteria E. coli D21 (MIC 0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B.
Evidence 34 Activity

Activity

MIC
Antiparasitic
0.2 µM

Target

P. syringae pv tabaci

Source & Reference

DRAMP

Other

0.2 uM), P. aeruginosa ATCC 15692 (MIC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. au
Evidence 35 Activity

Activity

MIC
Antiparasitic
0.4 µM

Target

E. agglomerans Bo-1S

Source & Reference

DRAMP

Other

IC 0.7 uM), Y. pseudotuberculosis YPIII (MIC 0.1 uM), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fung
Evidence 36 Activity

Activity

MIC
Antiparasitic
0.1 µM

Target

B. megaterium Bm11

Source & Reference

DRAMP

Other

M), P. syringae pv tabaci (MIC 0.2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Als
Evidence 37 Activity

Activity

MIC
Antiparasitic
0.4 µM

Target

Staphylococcus aureus Cowan I

Source & Reference

DRAMP

Other

2 uM), E. agglomerans Bo-1S (MIC 0.4 uM), Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC
Evidence 38 Activity

Activity

MIC
Antiparasitic
0.5 µM

Target

Candida albicans clinical isolate

Source & Reference

DRAMP

Other

Gram+ bacteria B. megaterium Bm11 (MIC 0.1 uM), S. aureus Cowan I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC
Evidence 39 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

V. harveyi ATCC33866

Source & Reference

DRAMP

Other

I (MIC 0.4 uM), and fungi C. albicans clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C.
Evidence 40 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

V. alginolyticus ATCC17749

Source & Reference

DRAMP

Other

s clinical isolate (MIC 0.5 uM). Also active against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fe
Evidence 41 Activity

Activity

MIC
Antiparasitic
6.25 µg/mL

Target

V. anguillarum ATCC19264

Source & Reference

DRAMP

Other

e against V. harveyi ATCC33866 (MIC 25 ug/ml), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC
Evidence 42 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

Citrobacter freundii ATCC43864

Source & Reference

DRAMP

Other

l), V. alginolyticus ATCC17749 (MIC 25 ug/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC1
Evidence 43 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

S. fexneri

Source & Reference

DRAMP

Other

g/ml), V. anguillarum ATCC19264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see th
Evidence 44 Activity

Activity

MIC
Antiparasitic
6.25 µg/mL

Target

S. saprophyticus

Source & Reference

DRAMP

Other

9264 (MIC 6.25 ug/ml), C. freundii ATCC43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see the 2024 ref above).
Evidence 45 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

L. monocytogenes ATCC19115

Source & Reference

DRAMP

Other

43864 (MIC 12.5 ug/ml), S. fexneri (MIC 50 ug/ml), S. saprophyticus (MIC 6.25 ug/ml), and L. monocytogenes ATCC19115 (MIC 50 ug/ml) (see the 2024 ref above).