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Peptide record

TPDB05152

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB05152
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KLLKLLKKLLKLLK
Physicochemical Analysis
C84H162N20O15
ARNDCEQGHIMFPSTWYV
L
1692.34
11.21
6
0
8
+6
1.46
0.500
222.86
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
8
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 8 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C84H162N20O15
1692.34
11.21
+6
1.46
0.500
Evidence Records 9 records
Evidence 1 Activity

Activity

IC50
Toxicity
9.3±1.1 µM
Cytotoxic
IC50 | 9.3±1.1 | µM | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells. | J Med Chem | 2016
Evidence 2 Activity

Activity

IC50
Toxicity
6.7±0.3 µM
Cytotoxic
IC50 | 6.7±0.3 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells. | J Med Chem | 2016
Evidence 3 Activity

Activity

IC50
Toxicity
5.1±0.2 µM
Cytotoxic
IC50 | 5.1±0.2 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Amphipathicity Determines Different Cytotoxic Mechanisms of Lysine- or Arginine-Rich Cationic Hydrophobic Peptides in Cancer Cells. | J Med Chem | 2016
Evidence 4 Activity

Activity

<=5% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
<=5% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 5 Activity

Activity

50% Cell death
Toxicity
3 µM
Cytotoxic
50% Cell death | 3 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 6 Activity

Activity

50% Cell death
Toxicity
10 µM
Cytotoxic
50% Cell death | 10 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 7 Activity

Activity

10% Hemolysis
Toxicity
0.625 µM
Hemolytic Cytotoxic
10% Hemolysis | 0.625 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Proline Hinged Amphipathic α-Helical Peptide Sensitizes Gram-Negative Bacteria to Various Gram-Positive Antibiotics. | J Med Chem | 2020
Evidence 8 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2016 Jun 9 59(11):5238-47.
Evidence 9 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis