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Peptide record

TPDB05150

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB05150
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
INWKGIAAMAKKLL
Physicochemical Analysis
C73H125N19O16S1
RDCEQHFPSTYV
AK
1556.97
10.84
3
0
9
+3
-0.93
0.529
132.86
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
353.25
1
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
3
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 3 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C73H125N19O16S1
1556.97
10.84
+3
-0.93
0.529
Evidence Records 14 records
Evidence 1 Activity

Activity

Hemolysis
Hemolysis
50 µg/mL
[Ref.16330062]Little hemolytic activity at 50 µg/ml against rabbit red blood cells

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Toxicon. 2006 Feb 47(2):249-253.##Peptides. 2006 Dec 27(12):3053-3057.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
25±1 µM
Hemolytic Cytotoxic
5% Hemolysis | 25±1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Side chain hydrophobicity modulates therapeutic activity and membrane selectivity of antimicrobial peptide mastoparan-X. | PLoS One | 2014
Evidence 3 Activity

Activity

5% Hemolysis
Toxicity
1.1±0.3 µM
Hemolytic Cytotoxic
5% Hemolysis | 1.1±0.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Side chain hydrophobicity modulates therapeutic activity and membrane selectivity of antimicrobial peptide mastoparan-X. | PLoS One | 2014
Evidence 4 Activity

Activity

2% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 32 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011
Evidence 5 Activity

Activity

7% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 64 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011
Evidence 6 Activity

Activity

22% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
22% Hemolysis | 128 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011
Evidence 7 Activity

Activity

47% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
47% Hemolysis | 256 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011
Evidence 8 Activity

Activity

2% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011
Evidence 9 Activity

Activity

4% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011
Evidence 10 Activity

Activity

10% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011
Evidence 11 Activity

Activity

35% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
35% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan. | Peptides | 2011
Evidence 12 Activity

Activity

5% Hemolysis
Toxicity
18±2 µM
Hemolytic Cytotoxic
5% Hemolysis | 18±2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Side chain hydrophobicity modulates therapeutic activity and membrane selectivity of antimicrobial peptide mastoparan-X. | PLoS One | 2014
Evidence 13 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.16330062]Little hemolytic activity at 50 µg/ml against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2006 Feb 47(2):249-253.##Peptides. 2006 Dec 27(12):3053-3057.
Evidence 14 Hemolysis

Activity

50 µg/mL
Hemolysis
[Ref.16330062]Little hemolytic activity at 50 µg/ml against rabbit red blood cells
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Toxicon. 2006 Feb 47(2):249-253.##Peptides. 2006 Dec 27(12):3053-3057.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.