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Peptide record

TPDB05140

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB05140
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept AI4AVP APD_complete APD_hemolytic Hemolytic2 ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
INIKDILAKLVKVLGHV
Physicochemical Analysis
C88H157N23O21
RCEQMFPSTWY
ILKV
1873.36
10.32
4
1
10
+2
3.02
1.000
194.71
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
1
N
1
D
0
C
0
E
0
Q
1
G
1
H
3
I
3
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 3 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
17
C88H157N23O21
1873.36
10.32
+2
3.02
1.000
Evidence Records 5 records
Evidence 1 Activity

Activity

Hemolysis
[Ref.2578459] Hemolysis: ED50=1.8±0.05 µg/ml. Histamine release: ED50=12.5±0.7 µg/ml against guinea pig erythrocytes.

Target

guinea pig erythrocytes

Source & Reference

APD_complete APD_hemolytic
DRAMP4
J Biol Chem. 1985 Feb 10 260(3):1437-144.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
1.8 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 1.8 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus | J Biol Chem | 1985
Evidence 3 Activity

Activity

50% Degranulation
Toxicity
12.5±0.7 µg/mL
Cytotoxic
50% Degranulation | 12.5±0.7 | µg/mL | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Bombolitins, a new class of mast cell degranulating peptides from the venom of the bumblebee Megabombus pennsylvanicus | J Biol Chem | 1985
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.2578459] Hemolysis: ED50=1.8±0.05 µg/ml. Histamine release: ED50=12.5±0.7 µg/ml against guinea pig erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 1985 Feb 10 260(3):1437-144.
Evidence 5 Hemolysis

Activity

[Ref.2578459] Hemolysis: ED50=1.8±0.05 µg/ml. Histamine release: ED50=12.5±0.7 µg/ml against guinea pig erythrocytes.
Hemolysis

Target

guinea pig erythrocytes

Source & Reference

APD_complete APD_hemolytic
J Biol Chem. 1985 Feb 10 260(3):1437-144.
DRAMP4
APD_complete APD_hemolytic