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Peptide record

TPDB05132

Antibacterial Antiparasitic Neurotoxin standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB05132
Antibacterial Antiparasitic Neurotoxin
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia dbAMP 3.0 i2APP NTxPred2
standard
No
A 50-aa standard natural multi-activity (Antibacterial, Antiparasitic, and Neurotoxin) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
DLWQFGKMILKVAGKLPFPYYGAYGCYCGWGGRGKPKDPTDRCCFVHDCC
Physicochemical Analysis
C257H374N66O65S7
NES
G
5652.62
8.29
8
4
18
+3
0.34
-0.266
46.80
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
17335
306.67
12
Residue Composition
number
2
A
2
R
0
N
4
D
6
C
0
E
1
Q
8
G
1
H
1
I
3
L
5
K
1
M
3
F
4
P
0
S
1
T
2
W
4
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 4 C: 6 E: 0 Q: 1 G: 8 H: 1 I: 1 L: 3 K: 5 M: 1 F: 3 P: 4 S: 0 T: 1 W: 2 Y: 4 V: 2
Chemical Descriptors
50
C257H374N66O65S7
5652.62
8.29
+3
0.34
-0.266
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Snake venom phospholipase A2 (PLA2). In vitro, shows anticoagulant activity and induces cytotoxicity when tested on C2C12 myoblasts/myotubes. In vivo, when tested on mice, induces myotoxicity (intramuscular injection), edema (injection in the subplantar region) and lethality. Also induces neurotoxic effect on mouse neuromuscular preparations and has bactericidal activity on the Gram-negative bacteria E.coli (ATCC29648) and the Gram-positive S.aureus (ATCC 25923). The catalytic and anticoagulant activities of BnpTX-I are higher than those of BnpTX-II. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. {ECO:0000269|PubMed:15302537}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedi pauloensis)
Neurotoxin
Snake venom phospholipase A2 (PLA2). In vitro, shows anticoagulant activity and induces cytotoxicity when tested on C2C12 myoblasts/myotubes.
Basic phospholipase A2 BnpTX-1 (BnPTx-I) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Evidence at protein level
Antibiotic Antimicrobial Blood coagulation cascade inhibiting toxin Calcium Direct protein sequencing Disulfide bond Hemostasis impairing toxin Hydrolase Lipid degradation Lipid metabolism Metal-binding Myotoxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Antibiotic Antimicrobial Blood coagulation cascade inhibiting toxin Calcium Direct protein sequencing Disulfide bond Hemostasis impairing toxin Hydrolase Lipid degradation Lipid metabolism Metal-binding Myotoxin Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Basic phospholipase A2 BnpTX-1 (BnPTx-I) (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake