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Peptide record

TPDB05124

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05124
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb AI4AVP AVPpred-BWR dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIPCGESCVWIPCISAALGCSCKNKVCYRN
Physicochemical Analysis
C134H216N38O39S6
DQHMFT
C
3175.78
8.02
3
1
10
+2
1.05
0.417
78.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
231.91
12
Residue Composition
number
2
A
1
R
2
N
0
D
6
C
1
E
0
Q
3
G
0
H
3
I
1
L
2
K
0
M
0
F
2
P
3
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 1 K: 2 M: 0 F: 0 P: 2 S: 3 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
30
C134H216N38O39S6
3175.78
8.02
+2
1.05
0.417
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>500 µM

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S.
Evidence 2 Activity

Activity

MIC
Antibacterial
54.6 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.
Evidence 3 Activity

Activity

MIC
Antibacterial
>500 µM

Target

K.oxytoca

Source & Reference

dbAMP DRAMP

Other

gainst Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM),
Evidence 4 Activity

Activity

MIC
Antibacterial
0.19 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

M), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C.
Evidence 5 Activity

Activity

MIC
Antibacterial
>500 µM

Target

M.luteus

Source & Reference

dbAMP DRAMP

Other

0 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM)
Evidence 6 Activity

Activity

MIC
Antibacterial
18.6 µM

Target

C. kefyr

Source & Reference

dbAMP DRAMP

Other

, Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also
Evidence 7 Activity

Activity

MIC
Antibacterial
19.4 µM

Target

C. tropicalis

Source & Reference

dbAMP DRAMP

Other

uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also inhibited HIV-1 infection in cul
Evidence 8 Activity

Activity

MIC
Antifungal
>500 µM

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S.
Evidence 9 Activity

Activity

MIC
Antifungal
54.6 µM

Target

P. vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.
Evidence 10 Activity

Activity

MIC
Antifungal
>500 µM

Target

K.oxytoca

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

gainst Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM),
Evidence 11 Activity

Activity

MIC
Antifungal
0.19 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C.
Evidence 12 Activity

Activity

MIC
Antifungal
>500 µM

Target

M.luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM)
Evidence 13 Activity

Activity

MIC
Antifungal
18.6 µM

Target

C. kefyr

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also
Evidence 14 Activity

Activity

MIC
Antifungal
19.4 µM

Target

C. tropicalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also inhibited HIV-1 infection in cul
Evidence 15 Activity

Activity

MIC
Antiparasitic
>500 µM

Target

E.coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S.
Evidence 16 Activity

Activity

MIC
Antiparasitic
54.6 µM

Target

P. vulgaris

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.
Evidence 17 Activity

Activity

MIC
Antiparasitic
>500 µM

Target

K.oxytoca

Source & Reference

dbAMP 3.0 DRAMP

Other

gainst Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM),
Evidence 18 Activity

Activity

MIC
Antiparasitic
0.19 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

M), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C.
Evidence 19 Activity

Activity

MIC
Antiparasitic
>500 µM

Target

M.luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

0 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM)
Evidence 20 Activity

Activity

MIC
Antiparasitic
18.6 µM

Target

C. kefyr

Source & Reference

dbAMP 3.0 DRAMP

Other

, Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also
Evidence 21 Activity

Activity

MIC
Antiparasitic
19.4 µM

Target

C. tropicalis

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also inhibited HIV-1 infection in cul
Evidence 22 Activity

Activity

MIC
Antiviral
>500 µM

Target

E.coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S.
Evidence 23 Activity

Activity

MIC
Antiviral
54.6 µM

Target

P. vulgaris

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.
Evidence 24 Activity

Activity

MIC
Antiviral
>500 µM

Target

K.oxytoca

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

gainst Gram- E.coli (MIC >500 uM), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM),
Evidence 25 Activity

Activity

MIC
Antiviral
0.19 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

M), P.aeruginosa (MIC> 500 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C.
Evidence 26 Activity

Activity

MIC
Antiviral
>500 µM

Target

M.luteus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

0 uM), P. vulgaris (MIC 54.6 uM), K.oxytoca (MIC >500 uM), Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM)
Evidence 27 Activity

Activity

MIC
Antiviral
18.6 µM

Target

C. kefyr

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

, Gram+ S. aureus (MIC 0.19 uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also
Evidence 28 Activity

Activity

MIC
Antiviral
19.4 µM

Target

C. tropicalis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

uM), M.luteus (MIC >500 uM), fungi C.albicans (MIC > 500 uM), C. kefyr (MIC 18.6 uM), and C. tropicalis (MIC 19.4 uM) (See ref AP00729, Tam JP et al. PNAS 96:8913-8). It also inhibited HIV-1 infection in cul
Evidence 29 Activity

Activity

50% Hemolysis
Toxicity
1020 µM
Hemolytic Cytotoxic
50% Hemolysis | 1020 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides. | Proc Natl Acad Sci U S A | 1999
Evidence 30 Activity

Activity

IC50
Toxicity
0.5 µM
Cytotoxic
IC50 | 0.5 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Cyclotides as natural anti-HIV agents | Biopolymers | 2008
Evidence 31 Activity

Activity

EC50
Toxicity
1020 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.10430870] EC50 = 1020 µM against blood type A human erythrocytes. | Cytotoxicity: [Ref.18008336]CEM-SS cells:IC50=500 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biopolymers. 2008 90(1):51-60. doi: 10.1002/bip.20886. ##Proc Natl Acad Sci U S A. 1999 Aug 3 96(16):8913-8918.##J. Mol. Biol. 1999 285:333-345. ##Biochem Biophys Res Commun. 1996 Nov 12 228(2):632-8.