Back to search

Peptide record

TPDB05119

Antibacterial Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05119
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, PD_Hemolysis, and other sources, with an available 3D structural model.
Sequence
INWKKMAATALKMI
Physicochemical Analysis
C74H127N19O17S2
RDCEQGHFPSYV
AK
1619.06
10.84
3
0
9
+3
-0.47
0.371
105.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
339.70
2
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
3
K
2
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 3 M: 2 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C74H127N19O17S2
1619.06
10.84
+3
-0.47
0.371
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.9 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 3.9 ug/ml), P. aeruginosa (MIC 15.6 ug/ml), S. aureus (MIC 2.9 ug/ml), and B. subtilis (MIC 3.5 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
15.6 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 3.9 ug/ml), P. aeruginosa (MIC 15.6 ug/ml), S. aureus (MIC 2.9 ug/ml), and B. subtilis (MIC 3.5 ug/ml) ( de Souza et al.,2011 ).
Evidence 3 Activity

Activity

MIC
Antibacterial
2.9 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against E. coli (MIC 3.9 ug/ml), P. aeruginosa (MIC 15.6 ug/ml), S. aureus (MIC 2.9 ug/ml), and B. subtilis (MIC 3.5 ug/ml) ( de Souza et al.,2011 ).
Evidence 4 Activity

Activity

MIC
Antibacterial
3.5 µg/mL

Target

B. subtilis

Source & Reference

NA

Other

t E. coli (MIC 3.9 ug/ml), P. aeruginosa (MIC 15.6 ug/ml), S. aureus (MIC 2.9 ug/ml), and B. subtilis (MIC 3.5 ug/ml) ( de Souza et al.,2011 ).
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
37 µM
Hemolytic Cytotoxic
50% Hemolysis | 37 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Investigating the effect of different positioning of lysine residues along the peptide chain of mastoparans for their secondary structures and biological activities | Amino Acids | 2011
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis