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Peptide record

TPDB05111

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB05111
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SLFSLIKAGAKFLGKNLLKQGACYAACKASKQC
Physicochemical Analysis
C155H258N42O41S3
RDEHMPTWV
AK
3462.19
10.13
6
0
15
+6
-0.11
0.261
89.09
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1615
46.65
10
Residue Composition
number
6
A
0
R
1
N
0
D
3
C
0
E
2
Q
3
G
0
H
1
I
5
L
6
K
0
M
2
F
0
P
3
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 0 C: 3 E: 0 Q: 2 G: 3 H: 0 I: 1 L: 5 K: 6 M: 0 F: 2 P: 0 S: 3 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
33
C155H258N42O41S3
3462.19
10.13
+6
-0.11
0.261
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC 5 ug/ml), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E.
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 5 ug/ml), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data prov
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

l), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured
Evidence 4 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

ilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protozoan A. proteus at 25 ug/ml
Evidence 5 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC 5 ug/ml), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E.
Evidence 6 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 5 ug/ml), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data prov
Evidence 7 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

l), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured
Evidence 8 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protozoan A. proteus at 25 ug/ml
Evidence 9 Activity

Activity

MIC
Antiparasitic
5 µg/mL

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against M. luteus (MIC 5 ug/ml), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E.
Evidence 10 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against M. luteus (MIC 5 ug/ml), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data prov
Evidence 11 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

l), S. epidermidis, B. subtilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured
Evidence 12 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP 3.0 DRAMP

Other

ilis, P. putida, P. aeruginosa (MIC 50 ug/ml), S. dysentariae, E. coli (MIC 25 ug/ml) and K. pneumoniae (MIC 100 ug/ml). (MIC data provided by Chunfeng Wang). It also ruptured protozoan A. proteus at 25 ug/ml
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the skin of a Korean frog, Rana rugosa. | Biochem Biophys Res Commun | 1994
Evidence 14 Activity

Activity

1% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the skin of a Korean frog, Rana rugosa. | Biochem Biophys Res Commun | 1994
Evidence 15 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.7999137] It has 0.04% hemolytic activity at 0.1 µg/ml, 0.14% hemolytic activity at 1 µg/ml, 0.51% hemolytic activity at 10 µg/ml, 0.59% hemolytic activity at 100 µg/ml against human red blood cells.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 1994 Nov 30 205(1):948-954.