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Peptide record

TPDB05099

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB05099
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SMLSVLKNLGKVGLGFVACKINKQC
Physicochemical Analysis
C117H204N32O31S3
RDEHPTWY
LK
2651.28
10.17
4
0
11
+4
1.32
0.596
116.80
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
4.71
7
Residue Composition
number
1
A
0
R
2
N
0
D
2
C
0
E
1
Q
3
G
0
H
1
I
4
L
4
K
1
M
1
F
0
P
2
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 4 K: 4 M: 1 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
25
C117H204N32O31S3
2651.28
10.17
+4
1.32
0.596
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
70 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
50 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
70 µM

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 8 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
70 µM

Target

Candida albicans

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2 uM), S. aureus (MIC 50 uM), and C. albicans (MIC 70 uM).
Evidence 10 Activity

Activity

Hemolysis
Hemolysis
20 µg/mL
[Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochem Biophys Res Commun. 1998 Sep 29 250(3):589-592.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 11 Activity

Activity

0% Hemolysis
Toxicity
20 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 20 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ranatuerins: antimicrobial peptides isolated from the skin of the American bullfrog, Rana catesbeiana | Biochem Biophys Res Commun | 1998
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
140 µM
Hemolytic Cytotoxic
50% Hemolysis | 140 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial properties of the frog skin peptide, ranatuerin-1 and its [Lys-8]-substituted analog | Peptides | 2004
Evidence 13 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 1998 Sep 29 250(3):589-592.
Evidence 14 Hemolysis

Activity

20 µg/mL
Hemolysis
[Ref.9784389] It has no detectable hemolytic activity at aconcentration of 20µg/ml against human red blood cell.
Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochem Biophys Res Commun. 1998 Sep 29 250(3):589-592.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.