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Peptide record

TPDB05098

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05098
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP AI4AVP DRAVP 2.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLIGRVLSGIL
Physicochemical Analysis
C68H116N16O15
ANDCEQHKMTWY
L
1397.77
11.05
1
0
8
+1
-2.51
1.808
202.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
4
L
0
K
0
M
1
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 4 K: 0 M: 0 F: 1 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C68H116N16O15
1397.77
11.05
+1
-2.51
1.808
Evidence Records 26 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2.3 µM

Target

m. group A

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
uM), S. aureus Cowan 1 (LC 2.3 uM), Y. pseudotubercolosis (LC 2.0 uM), S. pyogenes beta hem. group A (MIC 1-2.3 uM), E. coli D21 (LC 11.9 uM), A.hydrophila Bo-3N (LC >360 uM), P.aeruginosa ATCC15692 (LC >3
Evidence 2 Activity

Activity

MIC
Antibacterial
6.2-100 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

ginosa ATCC15692 (LC >360 uM), and C. albicans (LC 3.4 uM) also S. aureus (MIC ~3-8 uM), E. coli (MIC 6.2-100 uM), and A. baumannii (MIC 24 uM), including parasites L. donovani and L. mexicana (Molecules
Evidence 3 Activity

Activity

MIC
Antibacterial
24 µM

Target

A. baumannii

Source & Reference

dbAMP DRAMP

Other

and C. albicans (LC 3.4 uM) also S. aureus (MIC ~3-8 uM), E. coli (MIC 6.2-100 uM), and A. baumannii (MIC 24 uM), including parasites L. donovani and L. mexicana (Molecules. 2015 Feb 6 20(2):2775-85 J
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP DRAMP

Other

s. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). It is also active against channel catfish virus (CCV) as
Evidence 5 Activity

Activity

MIC
Antifungal
1-2.3 µM

Target

m. group A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
uM), S. aureus Cowan 1 (LC 2.3 uM), Y. pseudotubercolosis (LC 2.0 uM), S. pyogenes beta hem. group A (MIC 1-2.3 uM), E. coli D21 (LC 11.9 uM), A.hydrophila Bo-3N (LC >360 uM), P.aeruginosa ATCC15692 (LC >3
Evidence 6 Activity

Activity

MIC
Antifungal
6.2-100 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ginosa ATCC15692 (LC >360 uM), and C. albicans (LC 3.4 uM) also S. aureus (MIC ~3-8 uM), E. coli (MIC 6.2-100 uM), and A. baumannii (MIC 24 uM), including parasites L. donovani and L. mexicana (Molecules
Evidence 7 Activity

Activity

MIC
Antifungal
24 µM

Target

A. baumannii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

and C. albicans (LC 3.4 uM) also S. aureus (MIC ~3-8 uM), E. coli (MIC 6.2-100 uM), and A. baumannii (MIC 24 uM), including parasites L. donovani and L. mexicana (Molecules. 2015 Feb 6 20(2):2775-85 J
Evidence 8 Activity

Activity

MIC
Antifungal
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

s. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). It is also active against channel catfish virus (CCV) as
Evidence 9 Activity

Activity

MIC
Antiparasitic
1-2.3 µM

Target

m. group A

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
uM), S. aureus Cowan 1 (LC 2.3 uM), Y. pseudotubercolosis (LC 2.0 uM), S. pyogenes beta hem. group A (MIC 1-2.3 uM), E. coli D21 (LC 11.9 uM), A.hydrophila Bo-3N (LC >360 uM), P.aeruginosa ATCC15692 (LC >3
Evidence 10 Activity

Activity

MIC
Antiparasitic
6.2-100 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

ginosa ATCC15692 (LC >360 uM), and C. albicans (LC 3.4 uM) also S. aureus (MIC ~3-8 uM), E. coli (MIC 6.2-100 uM), and A. baumannii (MIC 24 uM), including parasites L. donovani and L. mexicana (Molecules
Evidence 11 Activity

Activity

MIC
Antiparasitic
24 µM

Target

A. baumannii

Source & Reference

dbAMP 3.0 DRAMP

Other

and C. albicans (LC 3.4 uM) also S. aureus (MIC ~3-8 uM), E. coli (MIC 6.2-100 uM), and A. baumannii (MIC 24 uM), including parasites L. donovani and L. mexicana (Molecules. 2015 Feb 6 20(2):2775-85 J
Evidence 12 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP 3.0 DRAMP

Other

s. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). It is also active against channel catfish virus (CCV) as
Evidence 13 Activity

Activity

MIC
Antiviral
1-2.3 µM

Target

m. group A

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
uM), S. aureus Cowan 1 (LC 2.3 uM), Y. pseudotubercolosis (LC 2.0 uM), S. pyogenes beta hem. group A (MIC 1-2.3 uM), E. coli D21 (LC 11.9 uM), A.hydrophila Bo-3N (LC >360 uM), P.aeruginosa ATCC15692 (LC >3
Evidence 14 Activity

Activity

MIC
Antiviral
6.2-100 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

ginosa ATCC15692 (LC >360 uM), and C. albicans (LC 3.4 uM) also S. aureus (MIC ~3-8 uM), E. coli (MIC 6.2-100 uM), and A. baumannii (MIC 24 uM), including parasites L. donovani and L. mexicana (Molecules
Evidence 15 Activity

Activity

MIC
Antiviral
24 µM

Target

A. baumannii

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

and C. albicans (LC 3.4 uM) also S. aureus (MIC ~3-8 uM), E. coli (MIC 6.2-100 uM), and A. baumannii (MIC 24 uM), including parasites L. donovani and L. mexicana (Molecules. 2015 Feb 6 20(2):2775-85 J
Evidence 16 Activity

Activity

MIC
Antiviral
8 µM

Target

Corynebacterium jeikeium ATCC BAA-949

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

s. 2015 Feb 6 20(2):2775-85 J Biol Chem. 2005 Jan 14 280(2):984-90). Also active against C. jeikeium ATCC BAA-949 (MIC 8 uM) ( Bruno Casciaro et al., 2020 ). It is also active against channel catfish virus (CCV) as
Evidence 17 Activity

Activity

Hemolysis
[Ref.9022710] LC>120 µM against Human red blood cells. (LC: Lethal concentration)

Target

Human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Eur J Biochem. 1996 Dec 15 242(3):788-792.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 18 Activity

Activity

28% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
28% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta. | J Pept Sci | 2011
Evidence 19 Activity

Activity

13% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
13% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta. | J Pept Sci | 2011
Evidence 20 Activity

Activity

10% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
10% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta. | J Pept Sci | 2011
Evidence 21 Activity

Activity

4% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
4% Hemolysis | 5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta. | J Pept Sci | 2011
Evidence 22 Activity

Activity

1% Hemolysis
Toxicity
2.5 µM
Hemolytic Cytotoxic
1% Hemolysis | 2.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine scanning analysis and structure-function relationships of the frog-skin antimicrobial peptide temporin-1Ta. | J Pept Sci | 2011
Evidence 23 Activity

Activity

IC50
Toxicity
7.91 µg/mL
Cytotoxic
IC50 | 7.91 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Antimicrobial Activity of Selected Antimicrobial Peptides Against Planktonic Culture and Biofilm of Acinetobacter baumannii. | Probiotics Antimicrob Proteins | 2018
Evidence 24 Activity

Activity

1% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
1% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis. | Int J Antimicrob Agents | 2010
Evidence 25 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.9022710] LC>120 µM against Human red blood cells. (LC: Lethal concentration)

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 1996 Dec 15 242(3):788-792.
Evidence 26 Hemolysis

Activity

[Ref.9022710] LC>120 µM against Human red blood cells. (LC: Lethal concentration)
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Eur J Biochem. 1996 Dec 15 242(3):788-792.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.