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Peptide record

TPDB05070

Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB05070
Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 iACP-DRLF Antifungipept APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLILRKIVTAL
Physicochemical Analysis
C74H129N17O15
NDCEQGHMSWY
L
1496.94
11.49
2
0
9
+2
-1.70
1.715
210.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
1
K
0
M
1
F
1
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 1 M: 0 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C74H129N17O15
1496.94
11.49
+2
-1.70
1.715
Evidence Records 26 records
Evidence 1 Activity

Activity

MIC
Antibacterial
150 µg/mL

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
weakly active against E.coli (MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 87
Evidence 2 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Staphylococcus aureus NCTC 10788 or MRSA

Source & Reference

dbAMP DRAMP

Other

weakly active against E.coli (MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 126
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP DRAMP

Other

(MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginos
Evidence 4 Activity

Activity

MIC
Antibacterial
64 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also show
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

E. faecium NTCC 12697

Source & Reference

dbAMP DRAMP

Other

r MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also showed antiproliferative activity to t
Evidence 6 Activity

Activity

MIC
Antibacterial
128 µM

Target

P.aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP

Other

(MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also showed antiproliferative activity to t H838 (IC50 27.71 uM), PC-3 (IC50 32.13 uM
Evidence 7 Activity

Activity

MIC
Antifungal
150 µg/mL

Target

E.coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
weakly active against E.coli (MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 87
Evidence 8 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Staphylococcus aureus NCTC 10788 or MRSA

Source & Reference

dbAMP DRAMP Antifungipept

Other

weakly active against E.coli (MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 126
Evidence 9 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginos
Evidence 10 Activity

Activity

MIC
Antifungal
64 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also show
Evidence 11 Activity

Activity

MIC
Antifungal
16 µM

Target

E. faecium NTCC 12697

Source & Reference

dbAMP DRAMP Antifungipept

Other

r MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also showed antiproliferative activity to t
Evidence 12 Activity

Activity

MIC
Antifungal
128 µM

Target

P.aeruginosa ATCC 9027

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also showed antiproliferative activity to t H838 (IC50 27.71 uM), PC-3 (IC50 32.13 uM
Evidence 13 Activity

Activity

MIC
Antiparasitic
150 µg/mL

Target

E.coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
weakly active against E.coli (MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 87
Evidence 14 Activity

Activity

MIC
Antiparasitic
2-4 µM

Target

Staphylococcus aureus NCTC 10788 or MRSA

Source & Reference

DRAMP

Other

weakly active against E.coli (MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 126
Evidence 15 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Escherichia coli ATCC 8739

Source & Reference

DRAMP

Other

(MIC 150 ug/ml) ( PubMed1997 ). Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginos
Evidence 16 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

DRAMP

Other

Active against S. aureus NCTC 10788 or MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also show
Evidence 17 Activity

Activity

MIC
Antiparasitic
16 µM

Target

E. faecium NTCC 12697

Source & Reference

DRAMP

Other

r MRSA (MIC 2-4 uM), E. coli ATCC 8739 (MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also showed antiproliferative activity to t
Evidence 18 Activity

Activity

MIC
Antiparasitic
128 µM

Target

P.aeruginosa ATCC 9027

Source & Reference

DRAMP

Other

(MIC 32 uM), K. pneumoniae ATCC 43816 (MIC 64 uM), E. faecium NTCC 12697 (MIC 16 uM), and P.aeruginosa ATCC 9027 (MIC 128 uM). It also showed antiproliferative activity to t H838 (IC50 27.71 uM), PC-3 (IC50 32.13 uM
Evidence 19 Activity

Activity

% Hemolysis
Hemolysis
20 %
[Ref.6206053] Hemolysis is 20% of total at 10µg/ml against guinea pig red blood cell.

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Pept Res. 1997 Aug 50(2):88-93.##J Biol Chem. 1984 Aug 25 259(16):10106-10111.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 20 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Anoplin, a novel antimicrobial peptide from the venom of the solitary wasp Anoplius samariensis. | Biochim Biophys Acta | 2001
Evidence 21 Activity

Activity

10% Hemolysis
Toxicity
34.575 µM
Hemolytic Cytotoxic
10% Hemolysis | 34.575 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity. | Int J Mol Sci | 2023
Evidence 22 Activity

Activity

50% Hemolysis
Toxicity
120.654 µM
Hemolytic Cytotoxic
50% Hemolysis | 120.654 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity. | Int J Mol Sci | 2023
Evidence 23 Activity

Activity

IC50
Toxicity
31.23 µM
Cytotoxic
IC50 | 31.23 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity. | Int J Mol Sci | 2023
Evidence 24 Activity

Activity

22% Cytotoxicity
Toxicity
100 µM
Cytotoxic
22% Cytotoxicity | 100 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
A Designed Analog of an Antimicrobial Peptide, Crabrolin, Exhibits Enhanced Anti-Proliferative and In Vivo Antimicrobial Activity. | Int J Mol Sci | 2023
Evidence 25 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.6206053] Hemolysis is 20% of total at 10µg/ml against guinea pig red blood cell.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Res. 1997 Aug 50(2):88-93.##J Biol Chem. 1984 Aug 25 259(16):10106-10111.
Evidence 26 Hemolysis

Activity

20 %
% Hemolysis
[Ref.6206053] Hemolysis is 20% of total at 10µg/ml against guinea pig red blood cell.
Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
J Pept Res. 1997 Aug 50(2):88-93.##J Biol Chem. 1984 Aug 25 259(16):10106-10111.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.