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Peptide record

TPDB05068

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB05068
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLDSLKGFAATAGKGVLQSLLSTASCKLAKTC
Physicochemical Analysis
C142H246N38O44S2
RNEHIMPWY
L
3253.86
9.72
4
1
14
+3
0.44
0.548
106.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.84
10
Residue Composition
number
5
A
0
R
0
N
1
D
2
C
0
E
1
Q
4
G
0
H
0
I
7
L
4
K
0
M
1
F
0
P
4
S
3
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 1 C: 2 E: 0 Q: 1 G: 4 H: 0 I: 0 L: 7 K: 4 M: 0 F: 1 P: 0 S: 4 T: 3 W: 0 Y: 0 V: 1
Chemical Descriptors
33
C142H246N38O44S2
3253.86
9.72
+3
0.44
0.548
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

B. Subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 4 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

B. Subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 5 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 6 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 7 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

B. Subtilis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 8 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 9 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

strongly active against B. Subtilis (MIC 2 ug/ml), S. aureus (MIC 8 ug/ml), and E. coli (MIC 4 ug/ml). Updated 10/2015 GW.
Evidence 10 Activity

Activity

Hemolysis
[Ref.1449472] high hemolytic activity

Source & Reference

APD_complete APD_hemolytic
DRAMP4
Biochem Biophys Res Commun. 1992 Nov 30 189(1):184-190.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.
Evidence 11 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.1449472] high hemolytic activity

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 1992 Nov 30 189(1):184-190.
Evidence 12 Hemolysis

Activity

[Ref.1449472] high hemolytic activity
Hemolysis

Source & Reference

APD_complete APD_hemolytic
Biochem Biophys Res Commun. 1992 Nov 30 189(1):184-190.
DRAMP4
APD_complete APD_hemolytic