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Peptide record

TPDB05062

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

20 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05062

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPIIAGMAAKVICAITKKC

FASTA

>TPDB05062|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=20
FLPIIAGMAAKVICAITKKC

Formula C96H167N23O22S3

Absent Amino Acids RNDEQHSWY

Common Amino Acids AI

Mass 2091.70

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +3

Boman Index -0.68

Hydrophobicity 1.425

Aliphatic Index 132.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 5.98

Polar Residues 3

number

Amino Acid Distribution

A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 1 K: 3 M: 1 F: 1 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C96H167N23O22S3

Mass

2091.70

9.80

Net Charge

Boman Index

-0.68

Hydrophobicity

1.425

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 13 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 13 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 13 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 50 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 13 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against E. coli (MIC 50 uM), S. aureus (MIC 6 uM), and C. albicans (MIC 13 uM). Updated 5/2018.

Evidence 13 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Hemolysis

Activity Measurement 25 µM

Hemolysis Raw

[Ref.15556063]HC50=25 µM against human erythrocytes

Target

RBC Target human erythrocytes

Source & Reference

Database Source Hemolytik APD_complete APD_hemolytic PD_Hemolysis

Source DRAMP4

Reference

Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct 139(1-3):31-38.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). | Comp Biochem Physiol C Toxicol Pharmacol | 2004

Evidence 15 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 25 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.15556063]HC50=25 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct 139(1-3):31-38.

Evidence 16 Hemolysis

Activity

Activity Measurement 25 µM

Activity Endpoint HC50

Hemolysis Raw

[Ref.15556063]HC50=25 µM against human erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Reference

Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct 139(1-3):31-38.

Source DRAMP4

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.