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Peptide record

TPDB05058

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

16 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB05058

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 Antifungipept i2APP

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

IIEKLVNTALGLLSGL

FASTA

>TPDB05058|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=16
IIEKLVNTALGLLSGL

Formula C76H136N18O22

Absent Amino Acids RDCQHMFPWY

Common Amino Acids L

Mass 1654.02

PI 6.94

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 9

Net Charge -0

Boman Index 0.20

Hydrophobicity 1.300

Aliphatic Index 195.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 5 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C76H136N18O22

Mass

1654.02

6.94

Net Charge

-0

Boman Index

0.20

Hydrophobicity

1.300

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.au

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >10

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

am+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC1

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism M.luteus ATCC9341

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S.uberis (IC5

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.aureus ATCC29213

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S.uberis (IC50 >100 uM), Gram- E.cloacae ATCC130

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.epidermidis ATCC14990

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S.uberis (IC50 >100 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.uberis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC50 >100 uM), S.aureus ATCC29213 (IC50 >100 uM), S.epidermidis ATCC14990 (IC50 >100 uM), S.uberis (IC50 >100 uM), Gram- E.cloacae ATCC13047 (IC50 > 100 uM), and E.coli ATCC35218 (IC50 > 100 uM). Updated

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.au

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism M.luteus ATCC9341

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism S.aureus ATCC29213

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism S.epidermidis ATCC14990

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism S.uberis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism B.cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source DRAMP

Other

Evidence Text

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.au

Evidence 19 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism L. lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism L.innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism M.luteus ATCC9341

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism S.aureus ATCC29213

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism S.epidermidis ATCC14990

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism S.uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism B.cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism Enterococcus faecalis ATCC29212

Source & Reference

Database Source DRAMP

Other

Evidence Text

Specifically active against Gram+ B.cereus (IC50 >100 uM), E.faecalis ATCC29212 (IC50 >100 uM), L. lactis (IC50 25 uM), L.innocua (IC50 >100 uM), M.luteus ATCC9341 (IC50 >100 uM), S.au

Evidence 27 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 25 µM

Target

Target Organism L. lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism L.innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism M.luteus ATCC9341

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 30 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism S.aureus ATCC29213

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 31 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism S.epidermidis ATCC14990

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 32 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement >100 µM

Target

Target Organism S.uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text